The primary objective of this study was to identify preoperative factors that could be associated with positive resection margins. We also tried to analyze the local recurrence and overall survival in patients who received conservative treatment for early-stage breast cancer and correlate these parameters with preoperative factors. A retrospective examination was conducted on the medical records and pathological reports of 143 patients who underwent breast-conserving surgery (BCS) for breast cancer in our department from 2009 to 2017. Postoperative outcomes were assessed through phone contact and statistical analyses, including GraphPad Prism, and Fisher’s exact test, the Chi-square test, and the log-rank test were employed. The results revealed positive resection margins in 7.69% (11 cases) of the 143 patients, with an overall mortality rate of 16.66% for those with positive margins and 6.59% for those with negative margins. Statistical analysis indicated no significant differences in the overall (p= 0.5) or specific (p= 0.53) survival between the positive and negative margin groups. The positive margins were significantly associated with neoadjuvant chemotherapy (p< 0.0001) and the presence of ductal carcinoma in situ (DCIS) (p= 0.01). Among the analyzed factors, two out of sixteen were significantly linked to positive resection margins in BCS, emphasizing their importance in surgical management planning for early-stage breast cancer.
本研究的主要目的是识别可能与手术切缘阳性相关的术前因素。同时，我们尝试分析接受早期乳腺癌保乳治疗患者的局部复发率和总生存率，并将这些参数与术前因素进行关联分析。我们回顾性审查了2009年至2017年间在本科室接受乳腺癌保乳手术的143例患者的病历和病理报告。通过电话随访及统计分析（包括GraphPad Prism软件、Fisher精确检验、卡方检验和对数秩检验）评估术后结局。结果显示，143例患者中手术切缘阳性率为7.69%（11例），切缘阳性组总死亡率为16.66%，阴性组为6.59%。统计分析显示切缘阳性组与阴性组在总生存率（p=0.5）和特定生存率（p=0.53）方面均无显著差异。切缘阳性与新辅助化疗（p<0.0001）及导管原位癌（DCIS）的存在（p=0.01）显著相关。在分析的16个因素中，有两个因素与保乳手术切缘阳性显著相关，这强调了它们在早期乳腺癌手术管理规划中的重要性。
肿瘤(癌症)患者之家