文章：

肝脏炎性假瘤或肝内胆管癌，此乃问题所在：文献综述

Inflammatory Pseudotumor of the Liver or Intrahepatic Cholangiocarcinoma, That’s the Question: A Review of the Literature

原文发布日期：23 August 2024

DOI: 10.3390/cancers16172926

类型: Article

开放获取: 是

英文摘要：

An inflammatory pseudotumor of the liver is a rare tumor-like lesion composed of polymorphous inflammatory cell infiltrates and variable amounts of fibrosis that can often mimic a malignant liver neoplasm. The etiology of inflammatory pseudotumors of the liver is unknown; symptoms are faint and imaging non-specific. Thus, it is often hard to make a diagnosis preoperatively and it is not so rare to over-treat patients with this disease or vice versa. Thus, more profound knowledge is necessary to plan appropriate disease management. We reported our two cases and systematically searched the literature regarding IPTL. We selected articles published in English from four databases, PubMed, Scopus, Web of Science and Google Scholar, and we included only articles with consistent data. Twenty nine papers fulfilling criteria for the review were selected. The analysis of 69 cases published from 1953 confirmed that the risk factors are unclear, the imaging data is not specific, and biopsy is crucial but not so widely used in clinical practice due to the procedure’s related risks, and relatively low effectiveness and improvement in imaging analysis. Regarding treatment, surgeons have moved towards a more conservative attitude over the years due to better imaging quality and patient surveillance. However, surgery remains the modality of choice for most cases with an indeterminate diagnosis. Even if an inflammatory pseudotumor of the liver is a benign tumor with a good prognosis, not requiring any treatment in most cases, sometimes it remains challenging to differentiate it from ICC; therefore, there is a solid recommendation to manage this condition with a multidisciplinary team.

摘要翻译： 

肝脏炎性假瘤是一种罕见的肿瘤样病变，由多形性炎性细胞浸润和不同程度的纤维化构成，常与恶性肝脏肿瘤相似。肝脏炎性假瘤的病因尚不明确，症状轻微且影像学表现缺乏特异性。因此，术前诊断往往较为困难，临床上对该病患者过度治疗或治疗不足的情况并不少见。因此，需要更深入的认识以制定合适的疾病管理策略。本文报告了两例病例，并对有关肝脏炎性假瘤的文献进行了系统检索。我们从PubMed、Scopus、Web of Science和Google Scholar四个数据库中筛选了英文发表的文献，仅纳入数据一致的论文。最终选取了29篇符合综述标准的文章。对1953年以来发表的69例病例分析证实，其危险因素尚不明确，影像学数据缺乏特异性，活检虽至关重要，但由于操作相关风险及影像分析中相对较低的效能和改进，在临床实践中并未广泛应用。在治疗方面，随着影像质量的提升和患者监测的改进，外科医生近年来倾向于采取更为保守的态度。然而，对于大多数诊断不明确的病例，手术仍是首选治疗方式。尽管肝脏炎性假瘤是一种预后良好的良性肿瘤，多数情况下无需治疗，但有时仍难以与肝内胆管癌区分，因此强烈建议由多学科团队共同管理此类疾病。

原文链接：

Inflammatory Pseudotumor of the Liver or Intrahepatic Cholangiocarcinoma, That’s the Question: A Review of the Literature