文章：

肝脏与肠道癌症的时间生物学研究

Chronobiology of Cancers in the Liver and Gut

原文发布日期：23 August 2024

DOI: 10.3390/cancers16172925

类型: Article

开放获取: 是

英文摘要：

Circadian rhythms dictate the timing of cellular and organismal physiology to maintain homeostasis. Within the liver and gut, circadian rhythms influence lipid and glucose homeostasis, xenobiotic metabolism, and nutrient absorption. Disruption of this orchestrated timing is known to negatively impact human health and contribute to disease progression, including carcinogenesis. Dysfunctional core clock timing has been identified in malignant growths and may be used as a molecular signature of disease progression. Likewise, the circadian clock and its downstream effectors also represent potential for novel therapeutic targets. Here, the role of circadian rhythms in the pathogenesis of cancers of the liver and gut will be reviewed, and chronotherapy and chronopharmacology will be explored as potential treatment options.

摘要翻译： 

昼夜节律调控细胞与机体生理活动的时序以维持内稳态。在肝脏与肠道中，昼夜节律影响脂质与葡萄糖稳态、外源性物质代谢及营养吸收。已知这种协调时序的紊乱会对人类健康产生负面影响，并促进包括癌变在内的疾病进展。恶性增生组织中已发现核心时钟基因的时序功能失调，这可能作为疾病进展的分子标志。同样，生物钟及其下游效应器也代表着潜在的新型治疗靶点。本文将综述昼夜节律在肝脏与肠道癌症发病机制中的作用，并探讨时间疗法与时间药理学作为潜在治疗策略的可能性。

原文链接：

Chronobiology of Cancers in the Liver and Gut