文章：

肺癌的遗传分析与临床治疗：当前进展与未来方向

The Genetic Analysis and Clinical Therapy in Lung Cancer: Current Advances and Future Directions

原文发布日期：19 August 2024

DOI: 10.3390/cancers16162882

类型: Article

开放获取: 是

英文摘要：

Lung cancer, including both non-small cell lung cancer and small cell lung cancer, remains the leading cause of cancer-related mortality worldwide, representing 18% of the total cancer deaths in 2020. Many patients are identified already at an advanced stage with metastatic disease and have a worsening prognosis. Recent advances in the genetic understanding of lung cancer have opened new avenues for personalized treatments and targeted therapies. This review examines the latest discoveries in the genetics of lung cancer, discusses key biomarkers, and analyzes current clinical therapies based on this genetic information. It will conclude with a discussion of future prospects and potential research directions.

摘要翻译： 

肺癌，包括非小细胞肺癌与小细胞肺癌，仍是全球癌症相关死亡的首要原因，在2020年占癌症总死亡人数的18%。许多患者在确诊时已处于晚期并伴有转移性疾病，预后较差。近年来对肺癌遗传学认识的深入为个体化治疗和靶向疗法开辟了新途径。本综述梳理了肺癌遗传学的最新发现，探讨了关键生物标志物，并基于遗传信息分析了当前临床治疗策略。最后，文章对未来发展前景及潜在研究方向进行了展望。

原文链接：

The Genetic Analysis and Clinical Therapy in Lung Cancer: Current Advances and Future Directions