Pancreatic cancer demonstrates an ever-increasing incidence over the last years and represents one of the top causes of cancer-associated mortality. Cells of the tumor microenvironment (TME) interact with cancer cells in pancreatic ductal adenocarcinoma (PDAC) tumors to preserve cancer cells’ metabolism, inhibit drug delivery, enhance immune suppression mechanisms and finally develop resistance to chemotherapy and immunotherapy. New strategies target TME genetic alterations and specific pathways in cell populations of the TME. Complex molecular interactions develop between PDAC cells and TME cell populations including cancer-associated fibroblasts, myeloid-derived suppressor cells, pancreatic stellate cells, tumor-associated macrophages, tumor-associated neutrophils, and regulatory T cells. In the present review, we aim to fully explore the molecular landscape of the pancreatic cancer TME cell populations and discuss current TME targeting strategies to provide thoughts for further research and preclinical testing.
胰腺癌的发病率近年来持续攀升，已成为癌症相关死亡的主要原因之一。在胰腺导管腺癌（PDAC）肿瘤中，肿瘤微环境（TME）细胞通过与癌细胞相互作用，维持癌细胞代谢、抑制药物递送、增强免疫抑制机制，最终形成对化疗和免疫治疗的耐药性。新兴治疗策略针对TME的基因改变及其细胞群中的特定信号通路。PDAC细胞与TME细胞群（包括癌症相关成纤维细胞、髓源性抑制细胞、胰腺星状细胞、肿瘤相关巨噬细胞、肿瘤相关中性粒细胞及调节性T细胞）之间形成复杂的分子相互作用网络。本综述旨在系统阐述胰腺癌TME细胞群的分子特征，探讨当前靶向TME的治疗策略，为后续研究和临床前试验提供思路。
Precision Targeting Strategies in Pancreatic Cancer: The Role of Tumor Microenvironment
肿瘤(癌症)患者之家