Isocitrate dehydrogenase (IDH) wild-type glioblastoma (GBM) is a highly aggressive brain tumor with a high recurrence rate despite adjuvant treatment. This study aimed to evaluate the risk factors for non-local recurrence of GBM. In the present study, we analyzed 104 GBMs with a single lesion (non-multifocal or multicentric). Univariate analysis revealed that subventricular zone (SVZ) involvement was significantly associated with non-local recurrence (hazard ratio [HR]: 2.09 [1.08–4.05]). Tumors in contact with the trigone of the lateral ventricle tended to develop subependymal dissemination (p= 0.008). Ventricular opening via surgery did not increase the risk of non-local recurrence in patients with SVZ involvement (p= 0.190). A systematic review was performed to investigate the risk of non-local recurrence, and 21 studies were identified. A meta-analysis of previous studies confirmed SVZ involvement (odds ratio [OR]: 1.30 [1.01–1.67]) andO-6-methylguanine DNA methyltransferase promoter methylation (OR: 1.55 [1.09–2.20]) as significant risk factors for local recurrence. A time-dependent meta-analysis revealed a significant association between SVZ involvement and dissemination (HR: 1.69 [1.09–2.63]), while no significant association was found for distant recurrence (HR: 1.29 [0.74–2.27]). Understanding SVZ involvement and specific tumor locations associated with non-local recurrence provides critical insights for the management of GBM.
异柠檬酸脱氢酶（IDH）野生型胶质母细胞瘤（GBM）是一种高度侵袭性的脑肿瘤，尽管接受辅助治疗，其复发率仍居高不下。本研究旨在评估GBM非局部复发的危险因素。本研究分析了104例单病灶（非多灶性或多中心性）GBM患者。单因素分析显示，脑室下区（SVZ）受累与非局部复发显著相关（风险比[HR]：2.09 [1.08–4.05]）。与侧脑室三角区接触的肿瘤倾向于发生室管膜下播散（p=0.008）。对于SVZ受累患者，手术中开放脑室并未增加非局部复发风险（p=0.190）。通过系统综述探究非局部复发风险，共纳入21项研究。对既往研究的荟萃分析证实，SVZ受累（比值比[OR]：1.30 [1.01–1.67]）和O-6-甲基鸟嘌呤DNA甲基转移酶启动子甲基化（OR：1.55 [1.09–2.20]）是局部复发的重要危险因素。时变荟萃分析显示SVZ受累与肿瘤播散显著相关（HR：1.69 [1.09–2.63]），而与远处复发无显著关联（HR：1.29 [0.74–2.27]）。理解SVZ受累及与非局部复发相关的特定肿瘤位置，为GBM的治疗管理提供了重要依据。
肿瘤(癌症)患者之家