We aim to explore the possible association between ovarian cancer and the subsequent development of open-angle glaucoma (OAG) using the Taiwan Longitudinal Health Insurance Database (LHID) 2000. A retrospective cohort study was executed, and individuals with ovarian cancer were enrolled and age-matched (with a 1:4 ratio) to non-ovarian cancer individuals. A total of 4990 and 19,960 patients were put into the ovarian cancer and control groups. The main outcome was the presence of OAG according to the LHID 2000 codes. The Cox proportional hazard regression was adopted to demonstrate the adjusted hazard ratio (aHR) and 95% confidence interval (CI) of OAG between the ovarian cancer and control groups. There were a total of 241 and 1029 OAG cases observed in the ovarian cancer group and the control group, respectively. The incidence of OAG was significantly higher in the ovarian cancer group than in the control group according to multivariable analysis (aHR: 1.18, 95% CI: 1.02–1.37,p= 0.022). The ovarian cancer patients older than 60 years showed a significantly higher risk of OAG compared to the non-ovarian cancer individuals of the same age (aHR: 1.39, 95% CI: 1.16–1.63,p= 0.001). Additionally, ovarian cancer individuals with a disease interval of more than two years presented a significantly higher incidence of OAG than the non-ovarian cancer group (p< 0.05). In conclusion, ovarian cancer positively correlates with a high rate of subsequent OAG, especially in elderly persons with a long disease interval.
本研究旨在利用台湾2000年纵向健康保险数据库（LHID 2000），探讨卵巢癌与后续发生开角型青光眼（OAG）之间的潜在关联。通过开展回顾性队列研究，将卵巢癌患者与非卵巢癌人群按年龄以1:4的比例进行匹配。最终卵巢癌组纳入4990例患者，对照组纳入19,960例患者。主要结局指标为根据LHID 2000编码确定的OAG发生情况。采用Cox比例风险回归模型计算卵巢癌组与对照组间OAG的校正风险比（aHR）及其95%置信区间（CI）。结果显示，卵巢癌组与对照组分别观察到241例和1029例OAG病例。多变量分析表明，卵巢癌组的OAG发生率显著高于对照组（aHR：1.18，95% CI：1.02–1.37，p=0.022）。其中60岁以上卵巢癌患者较同年龄段非卵巢癌人群表现出显著更高的OAG风险（aHR：1.39，95% CI：1.16–1.63，p=0.001）。此外，病程超过两年的卵巢癌患者OAG发生率显著高于非卵巢癌组（p<0.05）。结论表明，卵巢癌与后续较高的OAG发生率呈正相关，尤其在病程较长的老年患者中更为显著。
肿瘤(癌症)患者之家