Immunotherapy has revolutionized the treatment of myeloid oncologic diseases, particularly for patients resistant to chemotherapy or ineligible for allogeneic stem cell transplantation due to age or fitness constraints. As our understanding of the immunopathogenesis of myeloid malignancies expands, so too do the treatment options available to patients. Immunotherapy in myeloid malignancies, however, faces numerous challenges due to the dynamic nature of the disease, immune dysregulation, and the development of immune evasion mechanisms. This review outlines the progress made in the field of immunotherapy for myeloid malignancies, addresses its challenges, and provides insights into future directions in the field.
免疫疗法已彻底改变了髓系肿瘤疾病的治疗格局，尤其为化疗耐药或因年龄或体能状况限制无法接受异基因造血干细胞移植的患者提供了新的治疗选择。随着对髓系恶性肿瘤免疫发病机制认识的不断深入，患者的治疗选择也日益丰富。然而，由于疾病动态演变、免疫失调及免疫逃逸机制的形成，髓系肿瘤免疫治疗仍面临诸多挑战。本文综述了髓系恶性肿瘤免疫治疗领域的最新进展，剖析当前面临的挑战，并对该领域的未来发展方向提出展望。
肿瘤(癌症)患者之家