Castration-resistant prostate cancer (CRPC) remains a significant therapeutic challenge due to its resistance to standard androgen deprivation therapy (ADT). The emergence of androgen receptor splice variant 7 (AR-V7) has been implicated in CRPC progression, contributing to treatment resistance. Current treatments, including first-generation chemotherapy, androgen receptor blockers, radiation therapy, immune therapy, and PARP inhibitors, often come with substantial side effects and limited efficacy. Natural compounds, particularly those derived from herbal medicine, have garnered increasing interest as adjunctive therapeutic agents against CRPC. This review explores the role of AR-V7 in CRPC and highlights the promising benefits of natural compounds as complementary treatments to conventional drugs in reducing CRPC and overcoming therapeutic resistance. We delve into the mechanisms of action underlying the anti-CRPC effects of natural compounds, showcasing their potential to enhance therapeutic outcomes while mitigating the side effects associated with conventional therapies. The exploration of natural compounds offers promising avenues for developing novel treatment strategies that enhance therapeutic outcomes and reduce the adverse effects of conventional CRPC therapies. These compounds provide a safer, more effective approach to managing CRPC, representing a significant advancement in improving patient care.
去势抵抗性前列腺癌（CRPC）因其对标准雄激素剥夺疗法（ADT）的抵抗性，仍是临床治疗中的重大挑战。雄激素受体剪接变异体7（AR-V7）的出现与CRPC进展密切相关，并导致治疗抵抗。当前治疗方法包括第一代化疗、雄激素受体阻断剂、放射治疗、免疫疗法及PARP抑制剂等，常伴随明显副作用且疗效有限。天然化合物，特别是源自草药的成分，作为CRPC辅助治疗药物日益受到关注。本文综述了AR-V7在CRPC中的作用，重点探讨了天然化合物作为常规药物补充治疗在减少CRPC进展和克服治疗抵抗方面的潜在优势。我们深入分析了天然化合物抗CRPC的作用机制，揭示其在提升治疗效果、减轻传统疗法副作用方面的潜力。对天然化合物的探索为开发新型治疗策略提供了前景广阔的途径，这些策略既能增强疗效，又能降低传统CRPC疗法的不良反应。这些化合物为CRPC管理提供了更安全有效的治疗选择，标志着在改善患者诊疗方面取得了重要进展。
肿瘤(癌症)患者之家