文章：

非酒精性脂肪性肝炎相关肝细胞癌的外科治疗意义

Surgical Implications for Nonalcoholic Steatohepatitis-Related Hepatocellular Carcinoma

原文发布日期：6 August 2024

DOI: 10.3390/cancers16162773

类型: Article

开放获取: 是

英文摘要：

Hepatocellular carcinoma (HCC) is an aggressive form of liver cancer that arises in a background of chronic hepatic injury. Metabolic syndrome-associated fatty liver disease (MAFLD) and its severe form, nonalcoholic steatohepatitis (NASH), are increasingly common mechanisms for new HCC cases. NASH-HCC patients are frequently obese and medically complex, posing challenges for clinical management. In this review, we discuss NASH-specific challenges and the associated implications, including benefits of minimally invasive operative approaches in obese patients; the value of y90 as a locoregional therapy; and the roles of weight loss and immunotherapy in disease management. The relevant literature was identified through queries of PubMed, Google Scholar, and clinicaltrials.gov. Provider understanding of clinical nuances specific to NASH-HCC can improve treatment strategy and patient outcomes.

摘要翻译： 

肝细胞癌（HCC）是一种侵袭性肝癌，常在慢性肝损伤背景下发生。代谢综合征相关脂肪肝病（MAFLD）及其严重形式——非酒精性脂肪性肝炎（NASH），正日益成为新发HCC病例的常见致病机制。NASH-HCC患者常伴有肥胖且病情复杂，为临床管理带来挑战。本文综述探讨了NASH特异性难题及其临床意义，包括微创手术对肥胖患者的优势、钇90作为局部区域治疗的价值，以及减重与免疫疗法在疾病管理中的作用。相关文献通过检索PubMed、Google Scholar及clinicaltrials.gov数据库获得。临床医师深入理解NASH-HCC特有的临床细微差异，有助于优化治疗策略并改善患者预后。

原文链接：

Surgical Implications for Nonalcoholic Steatohepatitis-Related Hepatocellular Carcinoma