Introduction: Leukemia history affects some radical prostatectomy (RP) patients. Although its prevalence and effect as an adverse risk factor are well known in cardiac surgery, the number of RP patients with a leukemia history, as well as their rate of adverse in-hospital outcomes, are unknown. Methods: We identified RP patients (National Inpatient Sample 2000–2019), stratified according to the presence or absence of a leukemia history. Descriptive analyses, propensity score matching (PSM, ratio 1:10), and multivariable logistic regression models were used. Results: Of 259,939 RP patients, 416 (0.2%) had a leukemia history. Their proportion increased from 0.1 to 0.2% covering the study span (p< 0.01). Leukemia history patients were older (median age, 64 vs. 62 years,p< 0.001). After PSM for age, insurance status, ethnicity, pelvic lymph node dissection, and Charlson Comorbidity Index, leukemia history RP patients exhibited higher rates of acute kidney injury (<2.6 vs. 0.9%; Odds Ratio [OR] 2.0,p= 0.02), more frequently underwent dialysis (3.6 vs. 1.9%; OR 1.9,p= 0.03), and more frequently had a length of stay exceeding one week (4.8 vs. 2.5%; OR 2.0,p= 0.006). Conclusions: Although leukemia history RP patients are rare, their numbers have increased. Renal complications and extended hospital stays are more frequent in those individuals.
引言：部分接受根治性前列腺切除术（RP）的患者具有白血病病史。尽管白血病作为不良风险因素在心脏手术中的患病率及影响已较为明确，但具有白血病病史的RP患者数量及其院内不良结局发生率尚不清楚。方法：我们识别了2000-2019年间国家住院患者样本库中的RP患者，根据是否具有白血病病史进行分层。采用描述性分析、倾向评分匹配（PSM，比例1:10）及多变量逻辑回归模型进行分析。结果：在259,939例RP患者中，416例（0.2%）具有白血病病史。研究期间该比例从0.1%上升至0.2%（p<0.01）。白血病病史患者年龄更大（中位年龄64岁 vs. 62岁，p<0.001）。经年龄、保险状态、种族、盆腔淋巴结清扫及查尔森合并症指数PSM匹配后，白血病病史RP患者表现出更高的急性肾损伤发生率（2.6% vs. 0.9%；比值比[OR] 2.0，p=0.02）、更频繁的透析治疗（3.6% vs. 1.9%；OR 1.9，p=0.03）及更常见的住院时间超过一周（4.8% vs. 2.5%；OR 2.0，p=0.006）。结论：尽管具有白血病病史的RP患者较为罕见，但其数量呈上升趋势。该类患者更易出现肾脏并发症并需要延长住院时间。
Adverse In-Hospital Outcomes after Radical Prostatectomy in Leukemia History Patients
肿瘤(癌症)患者之家