Background: The interplay between cancer cells and the immune system is crucial in cancer progression and treatment. In this regard, the tumor immune microenvironment and macroenvironment, marked by systemic inflammation markers and TILs, could be considered key prognostic factors in tumors, including oral and lung squamous cell carcinoma. Methods: We conducted a retrospective clinical study on patients with Oral Squamous Cell Carcinoma (OSCC) and Lung Squamous Cell Carcinoma (LUSCC), examining stages, comorbidities, treatments, and outcomes. We evaluated the prognostic significance of pre-surgical systemic inflammation markers and tumor microenvironment composition. Results: Associations were found between systemic inflammation markers—NLR, MLR, and PLR—and tumor microenvironment factors, such as TILs and CD8+ cell prevalence—elevated inflammation markers correlated with advanced stages. Specifically, NLR was prognostic in OSCC, whereas PLR was prognostic in LUSCC. Using a cutoff value, we divided our tumor samples into two prognostic groups. Moreover, TILs levels >15% of tumor stroma correlated with prolonged overall survival in both OSCC and LUSCC, while increased CD8+ expression was linked to extended disease-free survival in LUSCC. Discussion: Systemic inflammation markers and TILs can be valuable prognostic factors of survival, highlighting the immune response’s role in OSCC and LUSCC. Despite limited clinical integration of the presented cohorts due to a lack of standardization, we concluded that analyzing tumor immune profiles may offer novel prognostic insights. Conclusions: Future integration into cancer classification could improve risk stratification and treatment guidance.
背景：癌细胞与免疫系统之间的相互作用在癌症进展和治疗中至关重要。在这方面，以全身炎症标志物和肿瘤浸润淋巴细胞为特征的肿瘤免疫微环境和宏观环境，可被视为包括口腔鳞状细胞癌和肺鳞状细胞癌在内的肿瘤的关键预后因素。方法：我们对口腔鳞状细胞癌和肺鳞状细胞癌患者进行了一项回顾性临床研究，分析了疾病分期、合并症、治疗方案及预后结果。我们评估了术前全身炎症标志物及肿瘤微环境组成的预后意义。结果：研究发现全身炎症标志物——中性粒细胞与淋巴细胞比值、单核细胞与淋巴细胞比值及血小板与淋巴细胞比值——与肿瘤微环境因素（如肿瘤浸润淋巴细胞和CD8+细胞丰度）之间存在关联，炎症标志物升高与疾病晚期相关。具体而言，中性粒细胞与淋巴细胞比值在口腔鳞状细胞癌中具有预后价值，而血小板与淋巴细胞比值在肺鳞状细胞癌中具有预后意义。通过设定截断值，我们将肿瘤样本分为两个预后组。此外，肿瘤间质中肿瘤浸润淋巴细胞水平>15%与口腔鳞状细胞癌和肺鳞状细胞癌患者的总生存期延长相关，而CD8+表达增加与肺鳞状细胞癌患者的无病生存期延长相关。讨论：全身炎症标志物和肿瘤浸润淋巴细胞可作为有价值的生存预后因素，凸显了免疫反应在口腔鳞状细胞癌和肺鳞状细胞癌中的作用。尽管由于缺乏标准化，当前队列的临床整合有限，但我们认为分析肿瘤免疫特征可能提供新的预后见解。结论：未来将其纳入癌症分类体系有望改善风险分层并指导治疗决策。
肿瘤(癌症)患者之家