(1) Background: This prospective study aimed to assess the impact on quality of life (QoL) from pretreatment to 3 years after treatment in oropharyngeal carcinoma (OPC) survivors. (2) Methods: QoL was measured with the EORTC QLQ-C30 and EORTC QLQ-H&N35 scales before treatment and in the first and third years. (3) Results: Of 72 patients, 51 completed all questionnaires over 3 years. A variable deterioration of QoL scores was detected before treatment. Most items worsened significantly after treatment and during the first year and improved in the third year. Advanced-stage cancer and definitive chemoradiotherapy treatment showed the worst scores. At 3 years, patients who underwent surgery with adjuvant radiation therapy/chemotherapy had significantly better scores on global QoL and emotional functioning compared to those treated with definitive chemoradiotherapy, who also reported problems with sticky salivation and dry mouth. Patients treated with an open surgical approach showed significantly greater deterioration in physical and role functioning compared to transoral surgery. (4) Conclusions: This long-term prospective study is the first in Spain to use EORCT scales in a homogeneous group of OPC survivors. QoL was generally good, although patients needed a long period of time to recover from both cancer and side effects of treatment. Advanced-stage cancer and definitive chemoradiotherapy showed the worst scores.
(1) 背景：本前瞻性研究旨在评估口咽癌幸存者从治疗前至治疗后3年期间生活质量的变化情况。(2) 方法：采用EORTC QLQ-C30量表和EORTC QLQ-H&N35量表在治疗前、治疗后第一年及第三年进行生活质量评估。(3) 结果：72例患者中，51例完成三年全部问卷。治疗前即观察到生活质量评分存在不同程度的恶化。多数指标在治疗后及第一年内显著下降，至第三年有所改善。晚期癌症患者及接受根治性放化疗治疗者的评分最差。三年随访时，接受手术联合辅助放疗/化疗的患者在总体生活质量和情绪功能方面的评分显著优于根治性放化疗组，后者同时报告存在唾液黏稠和口干问题。与经口手术相比，开放式手术患者的躯体功能和角色功能出现更显著的恶化。(4) 结论：这项长期前瞻性研究是西班牙首次在同类口咽癌幸存者群体中应用EORTC量表。尽管患者需要较长时间从癌症及治疗副作用中恢复，但总体生活质量良好。晚期癌症及根治性放化疗患者的生活质量评分最差。
Impact of Treatment on Quality of Life in Oropharyngeal Cancer Survivors: A 3-Year Prospective Study
肿瘤(癌症)患者之家