This study aimed to investigate the efficacy and duration of multiple non-ablative intravaginal CO2 laser (V-lase®) cycles in breast cancer patients, gynecological and other pelvic cancers previously subjected to multiple oncological treatments. This prospective study enrolled women under the age of 65 years who reported vaginal symptoms. Data on the Vaginal Health Index (VHI), vaginal length (VL), vaginal pain measured using a Visual Analog Scale (VAS), and the Female Sexual Function Index (FSFI) were collected at baseline and before each laser application, and at subsequent follow-up visits. A total of 170 laser applications were performed on 113 women with various types of cancer. Most patients (57.5%) had received radiotherapy-based treatments before receiving laser treatment. Vaginal health parameters and sexual function improved significantly with each laser application. However, a temporary decline in these improvements occurred during the intervals between cycles. Such worsening was reversed with the subsequent cycle in all groups of patients, irrespective of the type of oncological treatments they had undergone. Multiple course vaginal laser therapy showed promising results as a potential treatment for vaginal atrophy in heavily treated gynecological and breast cancer patients, necessitating further research to determine the optimal time interval between cycles to ensure sustained positive effects.
本研究旨在探讨多次非消融性阴道内二氧化碳激光（V-lase®）治疗周期对既往接受过多种肿瘤治疗的乳腺癌患者及妇科与其他盆腔癌症患者的疗效及持续时间。这项前瞻性研究纳入了65岁以下主诉阴道症状的女性患者。分别在基线期、每次激光治疗前及后续随访时收集阴道健康指数（VHI）、阴道长度（VL）、视觉模拟量表（VAS）评估的阴道疼痛及女性性功能指数（FSFI）数据。研究共对113名不同类型癌症患者实施了170次激光治疗。多数患者（57.5%）在接受激光治疗前曾接受过放射治疗。每次激光治疗后阴道健康参数与性功能均显著改善，但在治疗周期间隔期间这些改善会出现暂时性下降。所有患者群体无论既往接受过何种肿瘤治疗，这种恶化情况均能在后续治疗周期中得到逆转。多疗程阴道激光治疗作为重度治疗的妇科及乳腺癌患者阴道萎缩的潜在疗法显示出良好前景，但需进一步研究以确定最佳治疗间隔时间，确保持续的积极疗效。
Laser Therapy in Heavily Treated Oncological Patients Improves Vaginal Health Parameters
肿瘤(癌症)患者之家