Background: Older cancer survivors in general are at greater risk for cancer-related cognitive impairment (CRCI), yet few studies have explored its association with health outcomes. This study examined the association between subjective and objective measures of cognitive function and physical function, frailty, and quality of life (QoL) among older breast cancer survivors. Materials and Methods: Older breast cancer survivors who reported cognitive concerns completed surveys on patient-reported cognitive function, physical function, frailty, and QoL as well as objective tests of visuospatial working memory and sustained attention. Data were analyzed using descriptive statistics and separate linear regression models. Results: A total of 219 female breast cancer survivors completed the study. Perceived cognitive abilities were associated with better physical function, frailty, and QoL (p≤ 0.001) while cognitive concerns were negatively related with these metrics (p≤ 0.001). Poorer visuospatial working memory and sustained attention were linked to increased frailty (p≤ 0.001–0.01), whereas poorer sustained attention was associated with poorer physical function (p< 0.01). Conclusions: Older breast cancer survivors with perceived cognitive impairment and poorer cognitive performance reported poorer physical functioning, increased frailty, and poorer QoL. These findings underscore the importance of assessing cognitive concerns and their associated outcomes in older breast cancer survivors.
背景：老年癌症幸存者通常面临更高的癌症相关认知障碍风险，但探讨其与健康结局关联的研究较少。本研究旨在分析老年乳腺癌幸存者主观与客观认知功能测量指标与躯体功能、衰弱及生活质量之间的关联。材料与方法：自述存在认知困扰的老年乳腺癌幸存者完成了患者自评认知功能、躯体功能、衰弱及生活质量的问卷调查，并接受了视觉空间工作记忆与持续注意力的客观测试。数据分析采用描述性统计与多元线性回归模型。结果：共219名女性乳腺癌幸存者完成研究。自评认知能力与更好的躯体功能、更低的衰弱程度及更高的生活质量呈正相关（p≤0.001），而认知困扰与这些指标呈负相关（p≤0.001）。较差的视觉空间工作记忆和持续注意力与更高的衰弱程度相关（p≤0.001-0.01），而较差的持续注意力与更低的躯体功能相关（p<0.01）。结论：存在自评认知障碍及客观认知表现较差的老年乳腺癌幸存者，其躯体功能更差、衰弱程度更高、生活质量更低。这些发现强调了评估老年乳腺癌幸存者认知问题及其相关健康结局的重要性。
肿瘤(癌症)患者之家