Since the initial identification of oncogenic Wnt in mice and Drosophila, the Wnt signaling pathway has been subjected to thorough and extensive investigation. Persistent activation of Wnt signaling exerts diverse cancer characteristics, encompassing tumor initiation, tumor growth, cell senescence, cell death, differentiation, and metastasis. Here we review the principal signaling mechanisms and the regulatory influence of pathway-intrinsic and extrinsic kinases on cancer progression. Additionally, we underscore the divergences and intricate interplays of the canonical and non-canonical Wnt signaling pathways and their critical influence in cancer pathophysiology, exhibiting both growth-promoting and growth-suppressing roles across diverse cancer types.
自致癌性Wnt在小鼠和果蝇中被首次发现以来，Wnt信号通路已受到全面而深入的研究。Wnt信号的持续激活展现出多种癌症特征，包括肿瘤发生、肿瘤生长、细胞衰老、细胞死亡、分化及转移。本文综述了该通路的主要信号传导机制，以及通路内源性及外源性激酶对癌症进展的调控作用。同时，我们重点阐述了经典与非经典Wnt信号通路之间的差异及复杂相互作用，及其在癌症病理生理学中的关键影响——在不同类型的癌症中，这些通路既能促进肿瘤生长，亦能发挥抑制生长的作用。
Unraveling Cancer’s Wnt Signaling: Dynamic Control through Protein Kinase Regulation
肿瘤(癌症)患者之家