文章：

紫外线增强荧光皮肤镜在基底细胞癌中的应用

Application of Ultraviolet-Enhanced Fluorescence Dermoscopy in Basal Cell Carcinoma

原文发布日期：28 July 2024

DOI: 10.3390/cancers16152685

类型: Article

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英文摘要：

Introduction: Basal cell carcinoma (BCC) is the most common non-melanoma skin cancer. The aim of the current study was to analyze the ultraviolet-enhanced fluorescence dermoscopy (UVFD) characteristics of BCCs. Methods: BCCs were evaluated under polarized dermoscopy (PD) and UVFD. The findings in PD were described using predefined parameters for dermoscopic evaluation in dermato-oncology. UVFD characteristics were determined based on personal observations, and included interrupted follicle pattern, absence of pink-orange or blue-green fluorescence, well-demarcated borders, and dark silhouettes. Results: In total, 163 BCCs were analyzed. Under UVFD, the interrupted follicle pattern (p< 0.001), absence of pink-orange fluorescence (p= 0.005) and well-demarcated borders (p= 0.031) were more frequently noted in BCCs < 5 mm than in bigger tumors. Lesions on the face showed clearly defined borders (p= 0.031) and interrupted follicle pattern (p< 0.001) more frequently than tumors located beyond the face. Nodular BCCs displayed interrupted follicle pattern (p= 0.001) and absence of pink-orange fluorescence (p< 0.001) more commonly than superficial subtypes. Non-pigmented BCCs more frequently showed lack of blue-green fluorescence (p= 0.007) and interrupted follicle pattern (p= 0.018) compared to pigmented variants. Conclusions: UVFD may be a valuable, complementary to PD, tool in the diagnosis of BCC, particularly in small tumors, lesions located on the face and nodular or non-pigmented subtypes.

摘要翻译： 

引言：基底细胞癌（BCC）是最常见的非黑色素瘤皮肤癌。本研究旨在分析基底细胞癌在紫外增强荧光皮肤镜（UVFD）下的特征。方法：通过偏振光皮肤镜（PD）和UVFD对基底细胞癌进行评估。PD下的观察结果采用皮肤肿瘤学中皮肤镜评估的预设参数进行描述。UVFD特征基于个人观察确定，包括毛囊中断模式、粉橙色或蓝绿色荧光缺失、边界清晰以及暗色轮廓。结果：共分析了163例基底细胞癌。在UVFD下，直径小于5毫米的基底细胞癌比更大肿瘤更频繁地表现出毛囊中断模式（p<0.001）、粉橙色荧光缺失（p=0.005）和边界清晰（p=0.031）。面部病灶比非面部肿瘤更频繁地显示清晰边界（p=0.031）和毛囊中断模式（p<0.001）。结节型基底细胞癌比浅表亚型更常见毛囊中断模式（p=0.001）和粉橙色荧光缺失（p<0.001）。与非色素型相比，色素型基底细胞癌更频繁地显示蓝绿色荧光缺失（p=0.007）和毛囊中断模式（p=0.018）。结论：UVFD可能是一种有价值的、与PD互补的诊断基底细胞癌的工具，尤其适用于小肿瘤、面部病灶以及结节型或非色素型亚型。

原文链接：

Application of Ultraviolet-Enhanced Fluorescence Dermoscopy in Basal Cell Carcinoma