Background:Port site metastasis (PSM) has been reported as a rare metastasis in women with endometrial carcinoma (EC). However, even more rarely, it has also been described in patients with low- or intermediate-risk EC. Unfortunately, knowledge appears limited on the topic.Objectives:Our objective was to systematically review the literature on PSM in low- or intermediate-risk EC.Search Strategy:A systematic review of the literature was performed by searching six electronic databases from their inception to January 2023.Selection Criteria:We included in our research all peer-reviewed studies which reported PSM in low- or intermediate-risk EC women.Data Collection and Analysis:Data on PSM were collected from the included studies and compared.Results:Seven studies with 13 patients (including our case) were included in the systematic review. PSM was reported in patients with low- or intermediate-risk EC independently from tumor histologic characteristics, endoscopic approach, lymph node staging type, number and site of the port, route of specimen removal, prevention strategies for PSM, and concomitant metastases. Among several proposed treatments, local resection and radiotherapy with or without chemotherapy might be the most appropriate ones. Nevertheless, the prognosis appears poor.Conclusions:In patients with low- or intermediate-risk EC, PSM can occur as a rare metastasis, regardless of tumor characteristics or surgical strategy. Unfortunately, no consensus has been reached regarding treatment, and the prognosis appears poor. Additional cases are needed in order to confirm and further explore this rare EC metastasis.
背景：端口部位转移（PSM）在子宫内膜癌（EC）女性中被报道为一种罕见的转移现象。然而，更为罕见的是，它也在低风险或中风险EC患者中被描述。遗憾的是，关于这一主题的知识似乎有限。 目的：我们的目标是系统性地回顾关于低风险或中风险EC中PSM的文献。 检索策略：通过检索六个电子数据库自建库至2023年1月的文献，进行了系统性文献回顾。 选择标准：我们纳入了所有报告低风险或中风险EC女性中PSM的同行评审研究。 数据收集与分析：从纳入的研究中收集PSM相关数据并进行比较。 结果：系统性回顾共纳入七项研究，涉及13名患者（包括我们的病例）。PSM在低风险或中风险EC患者中被报告，与肿瘤组织学特征、内镜手术方式、淋巴结分期类型、端口数量及位置、标本取出途径、PSM预防策略以及伴随转移无关。在多种提出的治疗方法中，局部切除联合或不联合化疗的放疗可能是最合适的治疗方式。然而，预后似乎较差。 结论：在低风险或中风险EC患者中，PSM可能作为一种罕见转移发生，与肿瘤特征或手术策略无关。遗憾的是，目前尚未就治疗方法达成共识，且预后似乎较差。需要更多病例来确认并进一步探索这种罕见的EC转移现象。
肿瘤(癌症)患者之家