文章：

理解Toll样受体9在乳腺癌中的作用

Understanding the Role of Toll-Like Receptors 9 in Breast Cancer

原文发布日期：27 July 2024

DOI: 10.3390/cancers16152679

类型: Article

开放获取: 是

英文摘要：

Breast cancer is a significant global issue, ranking as the second most common cancer among women worldwide and a leading cause of cancer-related deaths. Although the exact causes of this increase remain unclear, factors such as genetics, epigenetics, obesity, sedentary lifestyle, tobacco use, and vitamin D deficiency have been implicated. The Toll-like receptor 9 (TLR9) is recognized for its role in inflammation and innate immunity; however, its specific involvement in breast cancer pathogenesis requires further investigation. This study aims to systematically review the existing literature on TLR9 expression in normal and cancerous breast tissue, providing current knowledge and identifying gaps. Relevant articles in English were from PubMed, Scopus, and Google Scholar, with the inclusion criteria focusing on studies evaluating TLR9 mRNA and protein expression. The review found that TLR9 mRNA and protein exhibit variable expressions in both normal and cancerous breast tissue, highlighting the need for further research to clarify TLR9’s role in breast cancer.

摘要翻译： 

乳腺癌是全球性的重大健康问题，在世界范围内女性癌症发病率中位居第二，并成为癌症相关死亡的主要原因。尽管其发病率上升的确切原因尚不明确，但遗传因素、表观遗传学改变、肥胖、久坐生活方式、烟草使用以及维生素D缺乏等因素均被认为与之相关。Toll样受体9（TLR9）在炎症反应和先天免疫中具有重要作用，但其在乳腺癌发病机制中的具体作用仍需深入研究。本研究旨在系统综述正常乳腺组织与癌变组织中TLR9表达的现有文献，梳理当前认知并指出研究空白。通过检索PubMed、Scopus和Google Scholar数据库收录的相关英文文献，纳入标准聚焦于评估TLR9 mRNA及蛋白表达的研究。综述发现TLR9 mRNA和蛋白在正常与癌变乳腺组织中呈现差异性表达，这凸显了需要进一步研究以明确TLR9在乳腺癌中的作用机制。

原文链接：

Understanding the Role of Toll-Like Receptors 9 in Breast Cancer