Colorectal cancer (CRC) represents a significant global healthcare burden, with a particularly concerning rising incidence among younger adults. This trend may highlight potential links between diet, gut microbiome, and CRC risk. Novel therapeutic options have been increasingly based on the understanding of molecular mechanisms and pathways. The PI3K/AKT/mTOR pathway, a crucial cell growth regulator, offers a promising target for CRC therapy. mTOR, a key component within this pathway, controls cell growth, survival, and metabolism. Understanding the specific roles of defensins, particularly human β-Defensin 1 (HBD-1), in CRC is crucial. HBD-1 exhibits potent antimicrobial activity and may influence CRC development. Deciphering defensin expression patterns in CRC holds the promise of improved understanding of tumorigenesis, which may pave the way for improved diagnostics and therapies. This article reviews recent advances in understanding regarding how HBD-1 influences CRC initiation and progression, highlighting the molecular mechanisms by which it impacts CRC. Further, we describe the interaction between defensins and mTOR pathway in CRC.
结直肠癌（CRC）是全球范围内一项重大的医疗负担，其发病率在年轻人群中呈上升趋势，这一现象尤为令人担忧。这一趋势可能凸显了饮食、肠道微生物组与结直肠癌风险之间的潜在联系。基于对分子机制和信号通路的深入理解，新的治疗方案不断涌现。PI3K/AKT/mTOR通路作为关键的细胞生长调节因子，为结直肠癌治疗提供了一个前景广阔的作用靶点。mTOR是该通路中的核心组分，调控着细胞的生长、存活和代谢。明确防御素，特别是人β-防御素1（HBD-1）在结直肠癌中的具体作用至关重要。HBD-1具有强大的抗菌活性，并可能影响结直肠癌的发生发展。解析防御素在结直肠癌中的表达模式，有望增进对肿瘤发生机制的理解，从而为改进诊断和治疗方法铺平道路。本文综述了关于HBD-1如何影响结直肠癌发生与进展的最新研究进展，重点阐述了其影响结直肠癌的分子机制。此外，我们还探讨了防御素与mTOR通路在结直肠癌中的相互作用。
Defensins: Exploring Their Opposing Roles in Colorectal Cancer Progression
肿瘤(癌症)患者之家