Background: Hereditary breast and ovarian cancer syndrome (HBOC) predisposes women to an increased risk mainly of breast and tubo-ovarian cancer. The aim of the study is to investigate whether being diagnosed with HBOC syndrome is itself a risk factor for sexual dysfunction. Methods: An ad hoc questionnaire, including baseline demographic and clinical data, and the Sexual Function Questionnaire 28 (SFQ28) were administered to HBOC female carriers (study group) and to a control group. Results: After propensity score matching (1:1), we enrolled 202 women, 101 in the study group and 101 in the control group. In a multivariate analysis, we finally found that menopausal status was the only risk factor for a significant low score in the domains Desire (HR 0.66; CI95% 0.47–0.93;p= 0.017), Arousal (Lubrication) (HR 0.52; CI95% 0.34–0.80;p= 0.003), Arousal (Cognitive) (HR 0.64; CI95% 0.44–0.95;p= 0.027), and Orgasm (HR 0.33; CI95% (0.16–0.70;p= 0.004), independent of risk-reducing surgery for gynecological malignancy. Psycho-oncology support is a protective factor for the Enjoyment domain (HR 1.38; CI95% 1.05–1.81;p= 0.022). Conclusions: HBOC syndrome itself does not affect SFQ28 domains, while menopausal status significantly influences sexual health, with potential mitigating effects of psycho-oncological support.
背景：遗传性乳腺癌与卵巢癌综合征（HBOC）使女性罹患乳腺癌和输卵管卵巢癌的风险显著增加。本研究旨在探讨HBOC综合征诊断本身是否为性功能障碍的风险因素。方法：采用包含基线人口统计学与临床数据的专用问卷及性功能问卷28项（SFQ28），对HBOC女性携带者（研究组）与对照组进行评估。结果：经倾向评分匹配（1:1）后，共纳入202名女性，其中研究组101人，对照组101人。多变量分析最终显示，绝经状态是导致性欲（HR 0.66；95%CI 0.47–0.93；p=0.017）、性唤起（润滑）（HR 0.52；95%CI 0.34–0.80；p=0.003）、性唤起（认知）（HR 0.64；95%CI 0.44–0.95；p=0.027）及性高潮（HR 0.33；95%CI 0.16–0.70；p=0.004）领域评分显著降低的唯一风险因素，且独立于妇科恶性肿瘤风险降低手术的影响。心理肿瘤学支持是性愉悦领域的保护性因素（HR 1.38；95%CI 1.05–1.81；p=0.022）。结论：HBOC综合征本身不影响SFQ28各领域评分，而绝经状态显著影响性健康，心理肿瘤学支持可能具有缓解作用。
Sexual Function in Women Diagnosed with Hereditary Breast and Ovarian Cancer Syndrome
肿瘤(癌症)患者之家