Cholangiocarcinoma (CCA) is a type of primary liver cancer originating from the biliary tract epithelium, characterized by limited treatment options for advanced cases and low survival rates. This study aimed to establish an orthotopic mouse model for CCA and monitor tumor growth using PET/MR imaging. Murine CCA cells were implanted into the liver lobe of male C57BL/6J mice. The imaging groups included contrast-enhanced (CE) MR, CE-MR with static [18F]FDG-PET, and dynamic [18F]FDG-PET. Tumor volume and FDG uptake were measured weekly over four weeks. Early tumor formation was visible in CE-MR images, with a gradual increase in volume over time. Dynamic FDG-PET revealed an increase in the metabolic glucose rate (MRGlu) over time. Blood analysis showed pathological changes in liver-related parameters. Lung metastases were observed in nearly all animals after four weeks. The study concludes that PET-MR imaging effectively monitors tumor progression in the CCA mouse model, providing insights into CCA development and potential treatment strategies.
胆管癌（CCA）是一种起源于胆道上皮的原发性肝癌，其特点是晚期病例治疗选择有限且生存率较低。本研究旨在建立胆管癌原位小鼠模型，并利用PET/MR成像技术监测肿瘤生长。将小鼠胆管癌细胞植入雄性C57BL/6J小鼠的肝叶中。成像组包括对比增强（CE）MR、结合静态[18F]FDG-PET的CE-MR以及动态[18F]FDG-PET。在四周内每周测量肿瘤体积和FDG摄取情况。CE-MR图像可观察到早期肿瘤形成，且体积随时间逐渐增大。动态FDG-PET显示代谢葡萄糖率（MRGlu）随时间推移而增加。血液分析显示肝脏相关指标出现病理改变。四周后几乎所有动物均观察到肺转移。研究结论表明，PET-MR成像能有效监测胆管癌小鼠模型的肿瘤进展，为胆管癌的发展机制及潜在治疗策略提供了重要参考。
Characterization of a Syngeneic Orthotopic Model of Cholangiocarcinoma by [18F]FDG-PET/MRI
肿瘤(癌症)患者之家