SerpinB3, a member of the serine-protease inhibitor family, has emerged as a crucial player in various physiological and pathological processes. Initially identified as an oncogenic factor in squamous cell carcinomas, SerpinB3’s intricate involvement extends from fibrosis progression and cancer to cell protection in acute oxidative stress conditions. This review explores the multifaceted roles of SerpinB3, focusing on its implications in fibrosis, metabolic syndrome, carcinogenesis and immune system impairment. Furthermore, its involvement in tissue protection from oxidative stress and wound healing underscores its potential as diagnostic and therapeutic tool. Recent studies have described the therapeutic potential of targeting SerpinB3 through its upstream regulators, offering novel strategies for cancer treatment development. Overall, this review underscores the importance of further research to fully elucidate the mechanisms of action of SerpinB3 and to exploit its therapeutic potential across various medical conditions.
SerpinB3作为丝氨酸蛋白酶抑制剂家族成员，在多种生理及病理过程中发挥着关键作用。最初在鳞状细胞癌中被鉴定为致癌因子，其复杂功能已延伸至纤维化进展、癌症发展及急性氧化应激状态下的细胞保护机制。本文系统综述了SerpinB3的多重生物学功能，重点探讨其在纤维化、代谢综合征、肿瘤发生及免疫系统损伤中的病理意义。该蛋白在抗氧化应激组织保护及创伤愈合中的作用，更凸显其作为诊断标志物和治疗靶点的潜在价值。最新研究揭示了通过调控SerpinB3上游通路实现靶向治疗的可能性，为肿瘤治疗策略开发提供了新方向。本文强调需进一步深入研究SerpinB3的作用机制，以充分挖掘其在多种疾病治疗中的应用潜力。
SerpinB3: A Multifaceted Player in Health and Disease—Review and Future Perspectives
肿瘤(癌症)患者之家