Health-related quality of life (HRQoL) represents one of the most concerning aspects for cancer patients. The Healthy Eating Index (HEI) is an a priori diet quality index directly associated with health outcomes and HRQoL in cancer survivors in North American populations. We evaluated, in a Mediterranean population, the baseline associations between HEI-2015 and HRQoL in 492 women with breast cancer recruited in a DEDiCa lifestyle trial. Dietary data were obtained from 7-day food records; HRQoL was assessed through the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ C30) and the C30 Summary Score (SumSc). Analysis of variance and multivariable linear and log-gamma regression models were performed. Mean and standard deviation for HEI-2015 score was 68.8 ± 11.2; SumSc was 81.5 ± 12.9. Women with lower HEI-2015 score had higher BMI, were more frequently exposed to tobacco smoke and had fewer years of education. Patients with a HEI-2015 score greater than 68.7 (median value) showed a significant increase in SumSc of 4% (p= 0.02). HEI-2015 components also associated with SumSc were beans and greens (β = 1.04;p= 0.02). Weak associations were found for total vegetables and saturated fats. Higher diet quality in breast cancer survivors was associated with higher overall HRQoL in this cross-sectional analysis.
健康相关生活质量是癌症患者最为关注的方面之一。健康饮食指数作为先验性膳食质量指标，在北美人群中已被证实与癌症幸存者的健康结局及生活质量直接相关。本研究以地中海人群为对象，在DEDiCa生活方式试验招募的492名乳腺癌患者中，评估了HEI-2015指数与健康相关生活质量的基线关联。膳食数据通过7天饮食记录获取，生活质量采用欧洲癌症研究与治疗组织生活质量核心问卷30项及C30总分进行评估。通过方差分析、多变量线性回归及对数伽马回归模型分析发现：HEI-2015平均得分为68.8±11.2，生活质量总分为81.5±12.9。HEI-2015得分较低者具有更高的体重指数、更高的烟草暴露率及更短的教育年限。HEI-2015得分高于中位值68.7的患者，其生活质量总分显著提升4%（p=0.02）。在HEI-2015各组分中，豆类与绿叶蔬菜摄入量与生活质量总分呈正相关（β=1.04；p=0.02），而蔬菜总量与饱和脂肪仅呈现弱相关性。本横断面研究表明，乳腺癌幸存者的膳食质量与整体健康相关生活质量存在正向关联。
肿瘤(癌症)患者之家