Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a common and debilitating symptom experienced by cancer survivors. Despite the burden of CIPN-related symptoms, interventions remain limited. Objectives: This narrative review seeks to propose a framework for CIPN predisposing, precipitating, and perpetuating factors (3Ps), which will provide a foundation for future research and clinical interventions aimed at mitigating CIPN-related symptoms and morbidity. Methods: A comprehensive literature search was performed using PubMed, guided by keywords related to “chemotherapy-induced peripheral neuropathy.” Studies were limited to those with full text available in English. Results: Predisposing factors outlined in this framework, such as older age and comorbid conditions, can be used to identify patients who have a higher risk of developing CIPN. The major precipitating factor of CIPN is the delivery of chemotherapy to peripheral nerves, which may be mitigated via cryotherapy or compression therapy during chemotherapy. Perpetuating factors can offer insight into psychological, cognitive, and behavioral modifications that could be treatment targets for CIPN management. Conclusion: The proposed 3P model can guide the development of effective interventions for CIPN by suggesting modifiable psychological and behavioral treatment targets that may mitigate the impact of CIPN for cancer patients.
背景：化疗所致周围神经病变（CIPN）是癌症幸存者常见且具有致残性的症状。尽管CIPN相关症状带来沉重负担，但干预措施仍然有限。目的：本文通过叙述性综述提出CIPN易感因素、诱发因素及持续因素（3P）分析框架，为未来旨在减轻CIPN相关症状及并发症的临床干预研究提供理论基础。方法：以"化疗所致周围神经病变"为关键词在PubMed数据库进行系统性文献检索，限定纳入英文全文文献。结果：本框架提出的易感因素（如高龄与合并症）可用于识别CIPN高风险患者；CIPN主要诱发因素为化疗药物对周围神经的作用，可通过化疗期间冷疗或压迫疗法进行干预；持续因素则揭示了可作为CIPN治疗靶点的心理、认知及行为调节机制。结论：3P模型通过识别可调控的心理行为干预靶点，为开发有效干预方案提供理论指导，有望减轻CIPN对癌症患者的影响。
Chemotherapy-Induced Peripheral Neuropathy (CIPN): A Narrative Review and Proposed Theoretical Model
肿瘤(癌症)患者之家