Background:We present a detailed description and the preliminary results of our original technique for non-invasive three-dimensional tumor localization in the breast, which was created as an alternative to standard invasive tumor marking before neoadjuvant systemic therapy (NAST), aiming to enable adequate surgery after complete tumor regression.Methods:A detailed description of the technique is provided in the main text. The technique’s feasibility and precision were assessed in a single-arm, prospective study based on the histological parameters of the adequacy and rationality of the excision of completely regressed tumor beds.Results:Out of 94 recruited patients, 15 (16%) were deemed unsuitable, mainly due to the tumors’ inadequate ultrasound visibility. Among the 79 processed patients, 31 (39%) had complete clinical regression after NAST and were operated on using our technique. The histological parameters of surgical precision (signs of tumor regression: 24/31; microscopic cancer residues: 7/31) were verified in all excised specimens (100% precision). There were no positive margins in seven cases with microscopic residues, indicating our technique’s capacity to enable oncologically safe post-NAST surgery.Conclusions:The proposed technique is feasible and satisfactorily accurate in determining the location of regressed tumors, thus representing an alternative to invasive tumor marking, especially in surgical centers lacking trained staff and equipment for invasive marking. The technique’s limitations are mainly related to the inadequate ultrasound visibility of the tumor.
背景：本研究详细阐述并初步验证了我们原创的乳腺肿瘤无创三维定位技术。该技术旨在替代新辅助系统治疗（NAST）前常规的侵入性肿瘤标记方法，以实现肿瘤完全消退后的精准手术切除。 方法：正文部分提供了该技术的详细操作流程。本研究通过单臂前瞻性试验评估了该技术的可行性与精确性，评估依据为完全消退肿瘤床切除的充分性与合理性等组织学参数。 结果：在94例入组患者中，15例（16%）因肿瘤超声显像不佳等原因被判定不适合该技术。在79例接受技术处理的患者中，31例（39%）在NAST后达到临床完全缓解并采用本技术进行手术。所有切除标本均验证了手术精确性的组织学参数（肿瘤消退迹象：24/31；显微镜下癌残留：7/31），精确率达到100%。7例存在微观残留的病例均未出现切缘阳性，表明本技术能够实现NAST后肿瘤学安全的手术切除。 结论：本研究所提出的技术在确定消退肿瘤位置方面具有可行性且精确度良好，可作为侵入性肿瘤标记的替代方案，尤其适用于缺乏专业人员和设备进行侵入性标记的医疗中心。该技术的主要局限性与肿瘤超声显像不充分相关。
Non-Invasive 3D Breast Tumor Localization: A Viable Alternative to Invasive Tumor Marking
肿瘤(癌症)患者之家