This review comprehensively explores the complex interplay between extracellular vesicles (ECVs)/exosomes and circadian rhythms, with a focus on the role of this interaction in hepatocellular carcinoma (HCC). Exosomes are nanovesicles derived from cells that facilitate intercellular communication by transporting bioactive molecules such as proteins, lipids, and RNA/DNA species. ECVs are implicated in a range of diseases, where they play crucial roles in signaling between cells and their surrounding environment. In the setting of cancer, ECVs are known to influence cancer initiation and progression. The scope of this review extends to all cancer types, synthesizing existing knowledge on the various roles of ECVs. A unique aspect of this review is the emphasis on the circadian-controlled release and composition of exosomes, highlighting their potential as biomarkers for early cancer detection and monitoring metastasis. We also discuss how circadian rhythms affect multiple cancer-related pathways, proposing that disruptions in the circadian clock can alter tumor development and treatment response. Additionally, this review delves into the influence of circadian clock components on ECV biogenesis and their impact on reshaping the tumor microenvironment, a key component driving HCC progression. Finally, we address the potential clinical applications of ECVs, particularly their use as diagnostic tools and drug delivery vehicles, while considering the challenges associated with clinical implementation.
本综述全面探讨了细胞外囊泡（ECVs）/外泌体与昼夜节律之间复杂的相互作用，重点关注该相互作用在肝细胞癌（HCC）中的作用。外泌体是源自细胞的纳米囊泡，通过运输蛋白质、脂质和RNA/DNA等生物活性分子促进细胞间通讯。ECVs与多种疾病相关，在细胞及其周围环境之间的信号传导中发挥着关键作用。在癌症背景下，已知ECVs会影响癌症的发生和发展。本综述的范围涵盖所有癌症类型，综合了关于ECVs各种作用的现有知识。本综述的一个独特之处在于强调昼夜节律控制的外泌体释放和组成，突出了它们作为早期癌症检测和监测转移的生物标志物的潜力。我们还讨论了昼夜节律如何影响多种癌症相关通路，提出生物钟的紊乱可能改变肿瘤发展和治疗反应。此外，本综述深入探讨了生物钟组分对ECV生物发生的影响及其对重塑肿瘤微环境的作用，这是驱动HCC进展的关键组成部分。最后，我们讨论了ECVs的潜在临床应用，特别是它们作为诊断工具和药物递送载体的用途，同时考虑了与临床实施相关的挑战。
肿瘤(癌症)患者之家