文章：

肝细胞癌合并主要血管侵犯的治疗

The Treatment of Hepatocellular Carcinoma with Major Vascular Invasion

原文发布日期：14 July 2024

DOI: 10.3390/cancers16142534

类型: Article

开放获取: 是

英文摘要：

Vascular invasion of hepatocellular carcinoma involves tumor plugs in the main trunk of the portal vein, bile ducts, and veins, and it indicates poor prognosis. It is often associated with portal hypertension, which requires evaluation and management. Treatment includes hepatic resection, systemic pharmacotherapy, hepatic arterial infusion chemotherapy, and radiation therapy. Recurrence rates post-hepatic resection are high, and systemic drug therapy often has limited therapeutic potential in patients with a poor hepatic reserve. Single therapies are generally inadequate, necessitating combining multiple therapies with adjuvant and systemic pharmacotherapy before and after hepatectomy. This narrative review will provide an overview of the treatment of hepatocellular carcinoma with vascular invasion.

摘要翻译： 

肝细胞癌的血管侵犯涉及门静脉主干、胆管及静脉内的癌栓形成，通常预示着不良预后。该病症常伴随门静脉高压，需进行系统评估与临床管理。主要治疗手段包括肝切除术、全身性药物治疗、肝动脉灌注化疗及放射治疗。肝切除术后复发率较高，且对于肝功能储备较差的患者，全身性药物治疗往往疗效有限。单一疗法通常难以达到理想效果，因此需要在肝切除术前、后联合多种辅助治疗及全身性药物治疗。本综述将系统阐述伴有血管侵犯的肝细胞癌的综合治疗策略。

原文链接：

The Treatment of Hepatocellular Carcinoma with Major Vascular Invasion