This manuscript examines the synergistic potential of prospective real-world/time data/evidence (RWTD/E) and randomized controlled trials (RCTs) to enrich healthcare research and operational insights, with a particular focus on its impact within the sarcoma field. Through exploring RWTD/E’s capability to provide real-world/time, granular patient data, it offers an enriched perspective on healthcare outcomes and delivery, notably in the complex arena of sarcoma care. Highlighting the complementarity between RWTD/E’s expansive real-world/time scope and the structured environment of RCTs, this paper showcases their combined strength, which can help to foster advancements in personalized medicine and population health management, exemplified through the lens of sarcoma treatment. The manuscript further outlines methodological innovations such as target trial emulation and their significance in enhancing the precision and applicability of RWTD/E, underscoring the transformative potential of these advancements in sarcoma care and beyond. By advocating for the strategic incorporation of prospective RWTD/E into healthcare frameworks, it aims to create an evidence-driven ecosystem that significantly improves patient outcomes and healthcare efficiency, with sarcoma care serving as a pivotal domain for these developments.
本文探讨前瞻性真实世界/时间数据/证据与随机对照试验在丰富医疗健康研究和临床实践洞察方面的协同潜力，尤其聚焦其在肉瘤领域的影响。通过挖掘真实世界/时间数据/证据在提供实时、精细化患者数据方面的能力，本研究为医疗结果与服务体系提供了更丰富的观察视角，特别是在复杂的肉瘤诊疗领域。文章着重阐释了真实世界/时间数据/证据的广谱现实维度与随机对照试验结构化环境之间的互补关系，并以肉瘤治疗为例，展示二者结合如何推动个体化医疗与群体健康管理的发展。研究进一步阐述了目标试验模拟等方法学创新对提升真实世界/时间数据/证据精确度与适用性的重要意义，强调这些进展对肉瘤诊疗及其他医疗领域的变革性潜力。通过倡导将前瞻性真实世界/时间数据/证据战略性地整合到医疗体系中，本文旨在构建一个显著改善患者预后与医疗效率的证据驱动型生态系统，其中肉瘤诊疗领域将成为这些发展的关键实践场域。
肿瘤(癌症)患者之家