The prognosis of uveal melanoma is significantly influenced by the risk of metastasis, which varies according to clinical and genetic features. Driver mutations can predict the likelihood of disease progression and survival, although the data in the literature are inconsistent. This meta-analysis aimed to evaluate the prognostic significance of driver mutations, includingGNAQ,GNA11,BAP1, andSF3B1, in the advancement of uveal melanoma. A comprehensive search of databases yielded relevant studies, and data from 13 studies (848 eyes) were synthesized to assess the impact of these mutations on metastasis-free survival. TheBAP1mutation and negative immunohistochemistry were associated with a higher risk of metastasis (logHR = 1.44, 95% CI 1.05–1.83).GNAQ,GNA11, andSF3B1mutations did not show a significant increase in risk. In summary,BAP1has proven to reliably predict the likelihood of disease progression in uveal melanoma, while further studies are needed to establish the significance of other driver mutations.
葡萄膜黑色素瘤的预后显著受转移风险影响，该风险因临床和遗传特征而异。驱动基因突变可预测疾病进展和生存可能性，但现有文献数据存在不一致性。本荟萃分析旨在评估GNAQ、GNA11、BAP1和SF3B1等驱动基因突变在葡萄膜黑色素瘤进展中的预后意义。通过系统检索数据库获得相关研究，综合13项研究（848眼）数据评估这些突变对无转移生存期的影响。BAP1突变及免疫组化阴性表达与更高的转移风险相关（对数风险比=1.44，95%置信区间1.05-1.83）。GNAQ、GNA11和SF3B1突变未显示显著风险增加。综上所述，BAP1已被证实能可靠预测葡萄膜黑色素瘤的疾病进展可能性，而其他驱动基因突变的临床意义仍需进一步研究确认。
Impact of Driver Mutations on Metastasis-Free Survival in Uveal Melanoma: A Meta-Analysis
肿瘤(癌症)患者之家