Background: Despite improving surgical techniques and achieving more often complete debulking procedures, certain patients with advanced-stage ovarian cancer still have a very poor prognosis. The aim of the current paper is to investigate whether inflammatory and nutritional status can predict the long-term outcomes of ovarian cancer patients. Methods: A retrospective analysis of 57 cases diagnosed with advanced-stage ovarian cancer submitted to surgery as first intent therapy was carried out. In all cases, the preoperative status was determined by calculating the CRP/albumin ratio, as well as the Glasgow score, the modified Glasgow score and the prognostic nutritional index. Results: Patients presenting higher values of the CRP/albumin ratio, with a higher Glasgow score, modified Glasgow score and prognostic nutritional index (PNI), were more frequently associated with incomplete debulking surgery, a higher peritoneal carcinomatosis index and poorer overall survival (20 months versus 9 months for the CRP/albumin ratiop= 0.011, 42 versus 27 versus 12 months for the Glasgow scorep= 0.042, 50 versus 19 versus 12 months for the modified Glasgow score,p= 0.001, and 54 months versus 21 months,p= 0.011 for the prognostic nutritional index). Conclusions: A strong relationship between the nutritional and inflammatory status in advanced-stage ovarian cancer seems to exist.
背景：尽管手术技术不断改进，肿瘤细胞减灭术的完全切除率日益提高，但部分晚期卵巢癌患者的预后仍然极差。本研究旨在探讨炎症与营养状态是否能够预测卵巢癌患者的长期预后。方法：对57例接受初始手术治疗的晚期卵巢癌病例进行回顾性分析。所有病例均通过计算C反应蛋白/白蛋白比值、格拉斯哥评分、改良格拉斯哥评分及预后营养指数来评估术前状态。结果：C反应蛋白/白蛋白比值较高、格拉斯哥评分、改良格拉斯哥评分及预后营养指数较高的患者，更常出现肿瘤细胞减灭术不完全、腹膜癌指数较高及总生存期较差的情况（C反应蛋白/白蛋白比值：20个月对比9个月，p=0.011；格拉斯哥评分：42个月对比27个月对比12个月，p=0.042；改良格拉斯哥评分：50个月对比19个月对比12个月，p=0.001；预后营养指数：54个月对比21个月，p=0.011）。结论：晚期卵巢癌患者的营养状态与炎症状态之间可能存在密切关联。
肿瘤(癌症)患者之家