Head and neck cancers (HNC) are frequently associated with neurodegeneration. However, the association between HNC and Parkinson’s disease (PD) remains unclear. This study aimed to clarify the relationship between HNC and subsequent PD. This retrospective study used data from a nationally representative cohort. Patients with HNC were identified based on the presence of corresponding diagnostic codes. Participants without cancer were selected using 4:1 propensity score matching based on sociodemographic factors and year of enrollment; 2296 individuals without HNC and 574 individuals with HNC were included in the study. Hazard ratios (HR) for the incidence of PD in patients with HNC were calculated using 95% confidence intervals (CI). The incidence of PD was 4.17 and 2.18 per 1000 person-years in the HNC and control groups, respectively (adjusted HR = 1.89, 95% CI = 1.08–3.33). The HNC group also showed an increased risk of subsequent PD development. The risk of PD was higher in middle-aged (55–69 years) patients with HNC and oral cavity cancer. Our findings suggest that middle-aged patients with HNC have an increased incidence of PD, specifically those with oral cavity cancer. Therefore, our findings provide new insights into the development of PD in patients with HNC.
头颈部癌症常与神经退行性病变相关，但其与帕金森病之间的关联尚不明确。本研究旨在阐明头颈部癌症与后续帕金森病发病之间的关系。这项回顾性研究采用全国代表性队列数据，通过诊断代码识别头颈部癌症患者，并依据社会人口学特征及入组年份进行4:1倾向评分匹配选取无癌症对照人群。研究共纳入2296名非头颈部癌症参与者及574名头颈部癌症患者。通过95%置信区间计算头颈部癌症患者帕金森病的风险比。结果显示，头颈部癌症组与对照组的帕金森病发病率分别为每千人年4.17例与2.18例（校正后风险比=1.89，95%置信区间=1.08-3.33）。头颈部癌症患者后续罹患帕金森病的风险显著升高，其中55-69岁中年患者及口腔癌患者的风险尤为突出。本研究表明，头颈部癌症患者（特别是中年口腔癌患者）的帕金森病发病率显著上升，这为理解头颈部癌症患者帕金森病的发病机制提供了新的视角。
Head and Neck Cancer: A Potential Risk Factor for Parkinson’s Disease?
肿瘤(癌症)患者之家