Significance:Despite the widespread use of photodynamic therapy in clinical practice, there is a lack of personalized methods for assessing the sufficiency of photodynamic exposure on tumors, depending on tissue parameters that change during light irradiation. This can lead to different treatment results.Aim:The objective of this article was to conduct a comprehensive review of devices and methods employed for the implicit dosimetric monitoring of personalized photodynamic therapy for tumors.Methods:The review included 88 peer-reviewed research articles published between January 2010 and April 2024 that employed implicit monitoring methods, such as fluorescence imaging and diffuse reflectance spectroscopy. Additionally, it encompassed computer modeling methods that are most often and successfully used in preclinical and clinical practice to predict treatment outcomes. The Internet search engine Google Scholar and the Scopus database were used to search the literature for relevant articles.Results:The review analyzed and compared the results of 88 peer-reviewed research articles presenting various methods of implicit dosimetry during photodynamic therapy. The most prominent wavelengths for PDT are in the visible and near-infrared spectral range such as 405, 630, 660, and 690 nm.Conclusions:The problem of developing an accurate, reliable, and easily implemented dosimetry method for photodynamic therapy remains a current problem, since determining the effective light dose for a specific tumor is a decisive factor in achieving a positive treatment outcome.
意义：尽管光动力疗法在临床实践中广泛应用，但目前仍缺乏根据光照过程中变化的组织参数来评估肿瘤光动力暴露充分性的个性化方法，这可能导致不同的治疗效果。 目的：本文旨在对肿瘤个性化光动力治疗中采用的间接剂量监测设备与方法进行全面综述。 方法：本综述纳入2010年1月至2024年4月期间发表的88篇同行评议研究论文，这些研究采用了荧光成像和漫反射光谱等间接监测方法，同时涵盖了临床前和临床实践中最常用且成功预测治疗效果的计算机建模方法。文献检索通过谷歌学术搜索引擎和Scopus数据库进行。 结果：综述分析比较了88篇同行评议研究论文中提出的各种光动力治疗间接剂量测定方法。光动力疗法最常用的波长位于可见光和近红外光谱范围，如405、630、660和690纳米。 结论：开发准确、可靠且易于实施的光动力治疗剂量测定方法仍是当前亟待解决的问题，因为确定特定肿瘤的有效光剂量是获得积极治疗效果的决定性因素。
肿瘤(癌症)患者之家