文章：

胃癌细胞对宽带太赫兹辐射响应性的统计分析：有无对比纳米粒子条件下的比较

Statistical Analysis of Gastric Cancer Cells Response to Broadband Terahertz Radiation with and without Contrast Nanoparticles

原文发布日期：4 July 2024

DOI: 10.3390/cancers16132454

类型: Article

开放获取: 是

英文摘要：

The paper describes the statistical analysis of the response of gastric cancer cells and normal cells to broadband terahertz radiation up to 4 THz, both with and without the use of nanostructured contrast agents. The THz spectroscopy analysis was comparatively performed under the ATR procedure and transmission measurement procedure. The statistical analysis was conducted towards multiple pairwise comparisons, including a support medium (without cells) versus a support medium with nanoparticles, normal cells versus normal cells with nanoparticles, and, respectively, tumor cells versus tumor cells with nanoparticles. When generally comparing the ATR procedure and transmission measurement procedure for a broader frequency domain, the differentiation between normal and tumor cells in the presence of contrast agents is superior when using the ATR procedure. THz contrast enhancement by using contrast agents derived from MRI-related contrast agents leads to only limited benefits and only for narrow THz frequency ranges, a disadvantage for THz medical imaging.

摘要翻译： 

本文描述了胃癌细胞与正常细胞在有无纳米结构造影剂条件下，对高达4太赫兹的宽带太赫兹辐射响应的统计分析。太赫兹光谱分析分别在衰减全反射（ATR）测量程序与透射测量程序下进行对比研究。统计分析针对多组配对比较展开，包括：无细胞的支撑介质与含纳米颗粒的支撑介质、正常细胞与含纳米颗粒的正常细胞、以及肿瘤细胞与含纳米颗粒的肿瘤细胞。在较宽频率范围内综合比较ATR程序与透射测量程序时发现，使用造影剂的情况下，ATR程序在区分正常细胞与肿瘤细胞方面表现更优。使用源自MRI相关造影剂的太赫兹造影剂进行对比度增强，仅能在狭窄的太赫兹频率范围内产生有限效果，这对太赫兹医学成像应用构成显著局限。

原文链接：

Statistical Analysis of Gastric Cancer Cells Response to Broadband Terahertz Radiation with and without Contrast Nanoparticles