Appendiceal tumors are uncommon and, at times, discovered incidentally during histological examination. The histopathological classification of the disease is complex and has generated some controversy. The analysis of circulating tumor cells can be used for the early detection of metastatic potential. The aim of the present study was to examine the prognostic value of circulating tumor cells in patients with appendiceal tumors and peritoneal metastases. To our knowledge, this is the first study to examine CTCs in appendiceal tumors. We performed a prospective cohort study of consecutive patients treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy between 2015 and 2019 at a HIPEC referral center. In total, 31 patients were included in the analysis, and circulating tumor cells were detected in 15 patients (48%). CTC positivity was not associated with overall or recurrence-free survival, nor was it correlated with PCI score or histopathological grading. Surprisingly, however, CTCs were found in almost half the patients. The presence or quantities of these cells did not, on their own, predict systemic metastatic potential during the observed time, and they did not appear to significantly correlate with the oncological outcomes recorded.
阑尾肿瘤较为罕见，有时是在组织学检查中偶然发现的。该疾病的组织病理学分类复杂且存在一定争议。循环肿瘤细胞分析可用于早期检测转移潜能。本研究旨在探讨循环肿瘤细胞对阑尾肿瘤伴腹膜转移患者的预后价值。据我们所知，这是首个针对阑尾肿瘤循环肿瘤细胞的研究。我们在2015年至2019年间于某HIPEC转诊中心开展了一项前瞻性队列研究，纳入连续接受肿瘤细胞减灭术联合腹腔热灌注化疗治疗的患者。共计31例患者纳入分析，其中15例（48%）检测到循环肿瘤细胞。循环肿瘤细胞阳性与总生存期或无复发生存期无显著关联，亦未发现其与腹膜癌指数评分或组织病理学分级存在相关性。然而值得注意的是，近半数患者体内检测到循环肿瘤细胞。在观察期内，这些细胞的存在与否及其数量本身并不能预测系统性转移潜能，且与记录的肿瘤学结局未见显著相关性。
肿瘤(癌症)患者之家