The human endometrium experiences significant cyclic morphological and biochemical changes throughout the menstrual cycle to prepare for embryo implantation. These processes are meticulously regulated by ovarian steroids and various locally expressed genes, encompassing inflammatory reactions, apoptosis, cell proliferation, angiogenesis, differentiation (tissue formation), and tissue remodeling. MicroRNAs (miRNAs) have been recognized as crucial regulators of gene expression, with their altered expression being linked to the onset and progression of various disorders, including cancer. This review examines the expression of miRNAs in the endometrium and their potential regulatory roles under pathological conditions such as endometriosis, recurrent implantation failure and endometrial cancer. Given miRNAs’ critical role in maintaining gene expression stability, understanding the regulatory mechanisms of endometrial miRNAs and identifying their specific target genes could pave the way for developing preventive and therapeutic strategies targeting specific genes associated with these reproductive disorders.
人类子宫内膜在月经周期中经历显著的周期性形态和生化变化，为胚胎着床做准备。这些过程受到卵巢类固醇激素及多种局部表达基因的精密调控，涉及炎症反应、细胞凋亡、增殖、血管生成、分化（组织形成）及组织重塑等环节。微小核糖核酸（miRNAs）已被确认为基因表达的关键调控因子，其表达异常与包括癌症在内的多种疾病的发生发展密切相关。本文综述了子宫内膜中miRNAs的表达特征，及其在子宫内膜异位症、反复种植失败和子宫内膜癌等病理状态下的潜在调控作用。鉴于miRNAs在维持基因表达稳定性中的核心作用，深入解析子宫内膜miRNAs的调控机制并鉴定其特异性靶基因，可能为开发针对这些生殖疾病相关特定基因的预防与治疗策略开辟新途径。
Diagnostic Value and Molecular Function of MicroRNAs in Endometrial Diseases: A Systematic Review
肿瘤(癌症)患者之家