In the last decade, a group of Ca2+channels called Piezo were discovered, demonstrating a decisive role in the cellular response to mechanical stimuli and being essential in the biological behavior of cells regarding the extracellular compartment. Several investigations have suggested a potential role in carcinogenesis, with a tumor suppressor role in some cases but increased expression in several high-grade neoplasms. Regarding Piezo2 expression in mammary gland neoplasms, a protective role for Piezo2 was initially suggested, but a subsequent study demonstrated a relationship between Piezo2 expression and the highly aggressive triple-negative phenotype of breast carcinoma. A cohort of 125 patients with clinical follow-up was chosen to study Piezo2 expression and clarify its clinical implications using the same immunohistochemical evaluation performed for other breast carcinoma parameters. Fisher’s exact test was chosen to identify potential relationships between the different variables. A significant association was found with the Ki67 proliferation index, but not with mitoses. The tendency of most proliferative tumors was to have an increased score for Piezo2. A similar association was found between Piezo2 expression and perineural invasion.
过去十年间，一类名为Piezo的钙离子通道被发现，其在细胞对机械刺激的响应中发挥决定性作用，并对细胞在细胞外环境中的生物学行为至关重要。多项研究表明该通道在肿瘤发生中具有潜在作用，在某些情况下呈现抑癌功能，但在多种高级别肿瘤中表达上调。关于Piezo2在乳腺肿瘤中的表达，早期研究提示其具有保护作用，但后续研究证实Piezo2表达与乳腺癌高度侵袭性的三阴性表型存在关联。本研究选取125例具有临床随访资料的患者队列，采用与其他乳腺癌参数相同的免疫组化评估方法研究Piezo2表达，以阐明其临床意义。采用Fisher精确检验分析各变量间的潜在关联，结果显示Piezo2与Ki67增殖指数存在显著相关性，但与有丝分裂计数无关。多数高增殖性肿瘤倾向于呈现更高的Piezo2评分。同时发现Piezo2表达与神经侵犯存在类似关联。
Prognostic Evaluation of Piezo2 Channels in Mammary Gland Carcinoma
肿瘤(癌症)患者之家