文章：

莫氏显微外科手术治疗皮肤鳞状细胞癌

Mohs Micrographic Surgery for Cutaneous Squamous Cell Carcinoma

原文发布日期：28 June 2024

DOI: 10.3390/cancers16132394

类型: Article

开放获取: 是

英文摘要：

Background: The first-line treatment of the localized form of cutaneous squamous cell carcinoma (cSCC) remains surgical excision. Either conventional excision (CE) with margins or Mohs micrographic surgery (MMS) may be preferred, depending on the risk factors of cSCC, the characteristics of the tumor, and the available technical facilities. Methods: This article presents a systematic review of the current literature spanning from 1974 to 2023, comparing outcomes of cSCC treated with MMS versus cSCC treated with conventional excision. Results: Out of the 6821 records identified through the database search, a total of 156 studies were screened, of which 10 were included in the review. The majority of the included studies showed that treatment of cSCC with MMS consistently exhibits a significantly lower risk of recurrence compared to treatment with CE. In addition, MMS is emerging as the preferred technique for the resection of cSCC located in aesthetically or functionally challenging anatomical areas. Conclusion: The studies generally demonstrate that MMS is a safer and more effective treatment of cSCC than CE. Nevertheless, outcomes such as recurrence rates and cost-effectiveness should be assessed more precisely, in order to allow for a more tailored approach in determining the appropriate indication for the use of MMS.

摘要翻译： 

背景：局限性皮肤鳞状细胞癌（cSCC）的一线治疗仍以外科切除为主。根据cSCC的危险因素、肿瘤特征及现有技术条件，可选择传统切缘切除术（CE）或莫氏显微描记手术（MMS）。方法：本文系统回顾了1974年至2023年的现有文献，比较MMS与CE治疗cSCC的疗效差异。结果：通过数据库检索共获得6821条记录，经筛选最终纳入10项研究。多数研究表明，与CE相比，采用MMS治疗cSCC的复发风险显著降低。此外，对于位于美学或功能敏感解剖区域的cSCC，MMS正逐渐成为首选切除技术。结论：现有研究普遍证实MMS是比CE更安全有效的cSCC治疗方式。然而，仍需更精确评估复发率及成本效益等指标，以便在确定MMS适应证时实现更精准的个体化决策。

原文链接：

Mohs Micrographic Surgery for Cutaneous Squamous Cell Carcinoma