文章：

对于特定转移性激素敏感性前列腺癌患者，是否存在降阶梯治疗的机会？

Is There an Opportunity to De-Escalate Treatments in Selected Patients with Metastatic Hormone-Sensitive Prostate Cancer?

原文发布日期：26 June 2024

DOI: 10.3390/cancers16132331

类型: Article

开放获取: 是

英文摘要：

The treatment landscape for metastatic hormone-sensitive prostate cancer continues to evolve, with systemic treatment being the mainstay of current treatment. Prognostic and predictive factors such as tumour volume and disease presentation have been studied to assess responses to different treatments. Intensification and de-escalation strategies arouse great interest, so several trials are being developed to further personalize the therapy in these populations. Is there an optimal sequence and a possible option to de-intensify treatment in selected patients with a favourable profile? This and other goals will be the subject of this review.

摘要翻译： 

转移性激素敏感性前列腺癌的治疗格局持续演变，系统性治疗仍是当前治疗的主要手段。肿瘤负荷与疾病表现等预后及预测因素已被用于评估不同治疗方案的疗效。强化与降阶梯治疗策略引发广泛关注，多项临床试验正在开展以进一步实现该患者群体的个体化治疗。对于预后良好的特定患者群体，是否存在最佳治疗序贯方案及降阶梯治疗的可能性？这一议题及其他相关目标将是本综述探讨的重点。

原文链接：

Is There an Opportunity to De-Escalate Treatments in Selected Patients with Metastatic Hormone-Sensitive Prostate Cancer?