Gastric cancer (GC) survivors may be more likely to develop osteoporosis. However, few studies on the relationship between GC and osteoporosis have been conducted on large patient populations. We aimed to determine the incidence of osteoporosis and identify related factors by comparing patients with GC and matched controls using the Korean National Health Insurance Service—National Sample Cohort (KNHIS-NSC). This study included 9078 patients with GC and 36,312 controls (1:4 propensity score-matched for sex, age, residence, and income). The hazard ratio (HR) for osteoporosis was significantly greater for GC patients than for controls according to Charlson Comorbidity Index (CCI) score-adjusted models (adjusted HR = 1.13). Kaplan–Meier analysis revealed that the cumulative incidence of osteoporosis during the follow-up period commencing from the index date was significantly greater in GC patients than in the controls (p= 0.0087). A positive correlation of osteoporosis with GC was detected for those aged < 65 years, males, and those with CCI scores = 0. In conclusion, the study findings suggest that men with GC aged < 65 years may be at an increased risk for osteoporosis. Research into additional risk factors and the optimal timing of interventions are needed to prevent fractures and minimize bone loss in GC survivors.
胃癌幸存者可能更易罹患骨质疏松症。然而，目前针对胃癌与骨质疏松症关系的大规模人群研究仍较为有限。本研究基于韩国国民健康保险服务-国家样本队列数据库，通过对比胃癌患者与匹配对照组，旨在确定骨质疏松症发病率并识别相关风险因素。研究共纳入9078例胃癌患者及36312例对照组（按性别、年龄、居住地和收入进行1:4倾向评分匹配）。根据查尔森合并症指数校正模型分析显示，胃癌患者发生骨质疏松的风险比显著高于对照组（校正后HR=1.13）。Kaplan-Meier生存分析表明，从索引日期开始随访期间，胃癌患者的骨质疏松累积发病率显著高于对照组（p=0.0087）。在年龄<65岁、男性及查尔森合并症指数=0的亚组中，均观察到骨质疏松与胃癌呈正相关。综上所述，本研究提示年龄<65岁的男性胃癌患者可能面临更高的骨质疏松风险。未来需进一步探究其他风险因素并确定最佳干预时机，以预防骨折并最大限度减少胃癌幸存者的骨质流失。
肿瘤(癌症)患者之家