Early diagnosis and prognosis of cancer progression through biomarker profiling are crucial in managing colon cancer patients. Our research aimed to investigate the expression of miR-101-3p, miR-106a-5p, and miR-326 in tumor and adjacent healthy tissues of colon cancer patients and determine their potential diagnostic utility. This study included 40 patients divided into four groups according to the TNM staging classification. MiRNA expression was analyzed using qRT-PCR. The results showed that miR-101-3p, miR-106a-5p, and miR-326 are overexpressed in adjacent healthy tissues but decrease in advanced cancer stages. MiR-106a-5p and miR-326 are strongly correlated with colon cancer severity. These findings suggest that miRNA profiling could be useful for early diagnosis and prognosis in colon cancer management.
通过生物标志物分析实现癌症进展的早期诊断与预后评估，对结肠癌患者的临床管理至关重要。本研究旨在探讨结肠癌患者肿瘤组织与癌旁正常组织中miR-101-3p、miR-106a-5p和miR-326的表达特征，并评估其潜在诊断价值。研究纳入40例患者，根据TNM分期系统分为四组，采用实时定量PCR技术检测miRNA表达水平。结果显示：miR-101-3p、miR-106a-5p和miR-326在癌旁正常组织中呈高表达，但在晚期癌症阶段表达显著下降；其中miR-106a-5p和miR-326的表达水平与结肠癌严重程度呈强相关性。研究表明，miRNA表达谱分析可为结肠癌的早期诊断和预后评估提供重要参考。
Exploring miRNA Profiles in Colon Cancer: A Focus on miR101-3p, miR106a-5p, and miR326
肿瘤(癌症)患者之家