Lung resection represents the main curative treatment in lung cancer; however, this surgical process leads to several disorders in tissues and organs. Previous studies have reported cardiovascular, pulmonary, and muscular disturbances that affect the functional capacity of these patients in the short, mid, and long term. However, upper limb impairment has been scarcely explored in the long term, despite the relevance in the independence of the patients. The aim of this study was to characterize the upper limb impairment in survivors of lung cancer one year after pulmonary resection. In this observational trial, patients who underwent lung cancer surgery were compared to control, healthy subjects matched by age and gender. Upper limb musculoskeletal disorders (shoulder range of motion, pain pressure threshold, nerve-related symptoms) and functional capacity (upper limb exercise capacity) were evaluated one-year post-surgery. A total of 76 survivors of lung cancer and 74 healthy subjects were included in the study. Significant differences between groups were found for active shoulder mobility (p< 0.05), widespread hypersensitivity to mechanical pain (p< 0.001), mechanosensitivity of the neural tissue (p< 0.001), and upper limb exercise capacity (p< 0.001). Patients who undergo lung cancer surgery show upper limb musculoskeletal disorders and upper limb functional impairment after a one-year lung resection. This clinical condition could limit the functionality and quality of life of patients with lung cancer.
肺切除术是肺癌的主要根治性治疗手段，然而这一手术过程会导致组织和器官的多重功能障碍。既往研究报道了心血管、肺部和肌肉系统在短期、中期及长期影响患者功能状态的各种紊乱。尽管上肢功能障碍对患者生活独立性具有重要影响，但长期随访中对此问题的研究仍显不足。本研究旨在探讨肺癌患者肺切除术后一年的上肢功能障碍特征。在这项观察性试验中，我们将接受肺癌手术的患者与年龄性别匹配的健康对照组进行比较。术后一年评估上肢肌肉骨骼系统状况（肩关节活动度、痛觉压力阈值、神经相关症状）及功能状态（上肢运动能力）。研究共纳入76名肺癌术后生存者及74名健康受试者。组间比较显示在主动肩关节活动度（p<0.05）、广泛性机械痛觉过敏（p<0.001）、神经组织机械敏感性（p<0.001）及上肢运动能力（p<0.001）方面均存在显著差异。接受肺癌手术的患者在肺切除术后一年仍存在上肢肌肉骨骼系统障碍及上肢功能损伤，这种临床状况可能限制肺癌患者的功能状态与生活质量。
Musculoskeletal Disorders Related to Upper Limb Disability after One-Year Lung Cancer Resection
肿瘤(癌症)患者之家