The incidence of colorectal cancer (CRC) in the U.S. is declining in adults 50 years and older; however, recent studies suggest an increasing disease burden among adults under age 50. This study aims to compare the incidence, mortality, and mortality-to-incidence ratios (MIRs) of CRC in EU15+ countries to determine if similar age-stratified occurrences are observed across these countries with similar “Western lifestyle”-related risk factors. Incidence and mortality rates for CRC between 1990 and 2019 were extracted using the Global Burden of Disease database. The data were age-stratified into groups between ages 25–49, 50–69, and greater than 69 years. We observed that the incidence of CRC increased globally for all age groups, with the highest increase observed for males (75.9%) and females (27.7%) aged 25–49. A similar trend was observed in 15 of the 19 EU15+ countries for males and 16 of the 19 EU15+ countries for females aged 25–49. Global mortality rates decreased for all age groups in females but increased for males in all age groups. This raises concerns regarding potentially modifiable risk factors contributing to increased CRC development and underscores the importance of implementing standardized screening at an earlier stage to ensure adequate detection in the younger population.
在美国，50岁及以上成年人的结直肠癌发病率呈下降趋势；然而，近期研究表明50岁以下成年人的疾病负担正在加重。本研究旨在比较欧盟15国及其关联国家（EU15+）的结直肠癌发病率、死亡率及死亡-发病比，以探究这些具有相似"西方生活方式"风险因素的国家是否呈现类似的年龄分层发病特征。通过全球疾病负担数据库提取1990年至2019年结直肠癌发病与死亡率数据，并按年龄分为25-49岁、50-69岁及69岁以上三组。研究发现：全球各年龄组结直肠癌发病率均呈上升趋势，其中25-49岁男性增幅最高（75.9%），女性次之（27.7%）。在EU15+国家中，19国中有15国的25-49岁男性及16国的同年龄段女性呈现相似增长趋势。全球女性各年龄组死亡率普遍下降，而男性各年龄组死亡率均有所上升。这一现象引发对可调控风险因素导致结直肠癌发病率上升的担忧，并凸显了在年轻群体中实施早期标准化筛查以确保充分检出率的重要性。
肿瘤(癌症)患者之家