Cancer is a leading cause of death worldwide, and the effectiveness of treatment is consistently not at a satisfactory level. This review thoroughly examines the present knowledge and perspectives of honokiol (HON) in cancer therapeutics. The paper synthesizes critical insights into the molecular mechanisms underlying the observed anticancer effects, emphasizing both in vitro and in vivo studies. The effects of HON application, primarily in the common types of cancers, are presented. Because the therapeutic potential of HON may be limited by its physicochemical properties, appropriate delivery systems are sought to overcome this problem. This review discusses the effect of different nanotechnology-based delivery systems on the efficiency of HON. The data presented show that HON exhibits anticancer effects and can be successfully administered to the site of action. Honokiol exerts its anticancer activity through several mechanisms. Moreover, some authors used the combinations of classical anticancer drugs with HON. Such an approach is very interesting and worth further investigation. Understanding HON’s multiple molecular mechanisms would provide valuable insights into how HON might be developed as an effective therapeutic. Therefore, further research is needed to explore its specific applications and optimize its efficacy in diverse cancer types.
癌症是全球范围内主要的致死原因，其治疗效果始终未能达到令人满意的水平。本文全面综述了和厚朴酚（HON）在癌症治疗中的现有认知与研究前景。文章系统整合了关于其抗癌作用分子机制的重要发现，重点涵盖了体外与体内实验研究。文中详细阐述了HON在常见癌症类型中的应用效果。鉴于HON的理化性质可能限制其治疗潜力，研究正寻求通过合适的递送系统以突破这一局限。本综述探讨了不同纳米技术递送系统对HON疗效的影响。现有数据表明，HON展现出抗癌活性，并能成功递送至靶向部位。其抗癌作用通过多种机制实现。此外，部分研究者尝试将传统抗癌药物与HON联合使用，这种联合治疗方案极具研究价值，值得深入探索。深入理解HON的多重分子机制，将为开发其作为有效治疗手段提供重要依据。因此，需要进一步研究以探索其在各类癌症中的具体应用并优化其疗效。
The Anticancer Application of Delivery Systems for Honokiol and Magnolol
肿瘤(癌症)患者之家