Recent advancements have significantly enhanced our understanding of the crucial role animal microbiomes play in veterinary medicine. Their importance in the complex intestinal environment spans immune modulation, metabolic homeostasis, and the pathogenesis of chronic diseases. Dysbiosis, a microbial imbalance, can lead to a range of diseases affecting both individual organs and the entire organism. Microbial disruption triggers inflammatory responses in the intestinal mucosa and disturbs immune homeostasis, increasing susceptibility to toxins and their metabolites. These dynamics contribute to the development of intestinal lymphoma, necessitating rigorous investigation into the role of microbiota in tumorigenesis. The principles explored in this study extend beyond veterinary medicine to encompass broader human health concerns. There are remarkable parallels between the subtypes of lymphoproliferative disorders in animals and humans, particularly Hodgkin’s lymphoma and non-Hodgkin’s lymphoma. Understanding the etiology of a cancer of the lymphatic system formation is critical for developing both preventive strategies and therapeutic interventions, with the potential to significantly improve patient outcomes. The aim of this study is to discuss the optimal composition of the microbiome in dogs and cats and the potential alterations in the microbiota during the development of intestinal lesions, particularly intestinal lymphoma. Molecular and cellular analyses are also incorporated to detect inflammatory changes and carcinogenesis. A review of the literature on the connections between the gut microbiome and the development of lymphomas in dogs and cats is presented, along with potential diagnostic approaches for these cancers.
近期研究进展显著深化了我们对动物微生物组在兽医学中关键作用的理解。其在复杂肠道环境中的重要性涵盖免疫调节、代谢稳态及慢性疾病发病机制等多个方面。菌群失调作为一种微生物失衡状态，可引发累及单个器官乃至全身的一系列疾病。微生物紊乱会触发肠道黏膜的炎症反应并破坏免疫稳态，从而增加机体对毒素及其代谢产物的易感性。这些动态变化促进了肠道淋巴瘤的发生发展，因此有必要深入研究微生物群在肿瘤发生中的作用。本研究探讨的原理不仅适用于兽医学领域，更延伸至更广泛的人类健康议题。动物与人类淋巴增殖性疾病的亚型——特别是霍奇金淋巴瘤和非霍奇金淋巴瘤——存在显著相似性。理解淋巴系统肿瘤形成的病因学对于制定预防策略和治疗干预方案至关重要，有望显著改善患者预后。本研究旨在探讨犬猫微生物组的最佳构成，以及肠道病变（特别是肠道淋巴瘤）发展过程中微生物群可能发生的变化。研究同时纳入分子与细胞分析以检测炎症变化和癌变过程。本文综述了关于肠道微生物组与犬猫淋巴瘤发展关联的现有文献，并探讨了针对这些肿瘤的潜在诊断方法。
肿瘤(癌症)患者之家