Orbital and ocular adnexal lymphoma (OAL) affects the orbit and the surrounding structures and can arise as several subtypes with variable prognoses. We performed an observational study on the relationship between OAL subtype, diagnostic features, and prognosis to offer valuable insights into imaging techniques, such as Positron Emission Tomography with 2-deoxy-2-[fluorine-18] fluoro-D-glucose integrated with Computed Tomography (18F-FDG PET-CT), in predicting outcomes. With this aim, we retrospectively reviewed 99 patients with OALs, recording demographics, cancer subtype, location and treatment,18FDG avidity, and bone marrow positivity. We divided patients into Group 1 (those presenting with extranodal marginal zone lymphoma—EMZL) and Group 2, including all other subtypes. The primary outcome was long-term cancer-specific survival (CSS) based on key predictors, performed through Kaplan–Meier curves and the log-rank test, with ap< 0.05 significance threshold. The mean patient age was 67 years (57–75.5). The most frequent histopathologic subtypes were EMZL lymphoma in 69 patients (69.7%), small lymphocytic lymphoma (11.1%) and diffuse-large B-cell lymphoma (10.1%). Patients of Group 1 showed a better prognosis (CSS = 80%) compared to those of Group 2 (CSS = 60%) (p= 0.01). In patients with high-grade lymphoma, the occurrence of18FDG avidity (p= 0.003) and bone marrow positivity (p= 0.005) were related to a worse prognosis. In our group, EMZL was the most prominent subtype of OALs and exhibited the best prognosis, low 18FDG avidity, and bone marrow negativity. By observing specific patterns in radiological findings, it is possible to increase our understanding of disease progression, treatment response, and the overall prognosis in OAL patients.
眼眶及眼附属器淋巴瘤（OAL）可累及眼眶及其周围结构，并存在多种预后不同的亚型。本研究旨在通过观察性分析探讨OAL亚型、诊断特征与预后的关联，为影像学技术（如2-脱氧-2-[氟-18]氟代-D-葡萄糖正电子发射断层扫描/计算机断层扫描）在预后预测中的应用提供参考。我们回顾性分析了99例OAL患者的临床资料，记录人口统计学特征、肿瘤亚型、病灶位置、治疗方案、18F-FDG摄取活性及骨髓侵犯情况。将患者分为两组：第1组为结外边缘区淋巴瘤（EMZL）患者，第2组包含所有其他亚型。通过Kaplan-Meier曲线和对数秩检验（显著性阈值p<0.05），以关键预测因子评估长期肿瘤特异性生存率（CSS）。患者平均年龄67岁（57-75.5岁），最常见的组织病理亚型为EMZL（69例，69.7%），其次为小淋巴细胞淋巴瘤（11.1%）和弥漫性大B细胞淋巴瘤（10.1%）。第1组患者预后显著优于第2组（CSS分别为80%和60%，p=0.01）。在高级别淋巴瘤患者中，18F-FDG高摄取（p=0.003）与骨髓侵犯阳性（p=0.005）均提示预后不良。本研究中EMZL是OAL最主要的亚型，具有最佳预后特征，表现为低18F-FDG摄取活性且无骨髓侵犯。通过识别影像学特征中的特定模式，可深化对OAL疾病进展、治疗反应及总体预后的理解。
肿瘤(癌症)患者之家