Background: The aim of the study was to evaluate the impact of urine-sample HPV (human papillomavirus) testing on the effectiveness of screening for cervical cancer. Methods: The analysis was based on the results of a systematic review. Secondary studies were searched in the following medical databases: Medline, Embase, and the Cochrane Library. The results of the statistical tests presented in the article originate from research conducted by the authors of the included articles. Results: From a total of 1869 citations, 5 studies were included in this review. Sensitivity and specificity for the detection of any HPV from first-void urine samples were 87% [95% CI: (0.74; 0.94)] and 89% [95% CI: (0.81; 0.93)], respectively. Moreover, participants in the analyzed studies had indicated that they felt comfortable with urine testing. Conclusions: The development of methods to detect HPV infection in first-void urine samples and the application of this sampling method in widely available screening tests could significantly increase patients’ willingness to participate in testing.
背景：本研究旨在评估尿液样本人乳头瘤病毒（HPV）检测对宫颈癌筛查效果的影响。方法：本分析基于系统综述的结果，在Medline、Embase和Cochrane Library等医学数据库中检索了相关二次研究。文中统计检验结果来源于纳入文献作者开展的研究。结果：从总计1869篇文献中，最终纳入5项研究进行分析。晨尿样本检测任意型HPV的敏感度为87%[95% CI：(0.74；0.94)]，特异度为89%[95% CI：(0.81；0.93)]。此外，纳入研究的参与者普遍表示对尿液检测方式感到适应。结论：开发晨尿样本HPV感染检测方法，并将该采样方式应用于广泛可及的筛查检测，可显著提高患者参与检测的意愿。
肿瘤(癌症)患者之家