Gastrointestinal (GI) tumors pose a significant global health burden, necessitating the exploration of novel therapeutic approaches. Plasmacytoid dendritic cells (pDCs) play a crucial role in tumor immunity, exhibiting both anti-tumor and pro-tumor effects. This review aims to summarize the role of pDCs in different types of GI tumors and assess their potential as therapeutic targets. In gastric cancer, hepatocellular carcinoma, and intrahepatic cholangiocarcinoma, increased infiltration of pDCs was associated with a worse outcome, whereas in esophageal cancer, pancreatic cancer, and colorectal cancer, pDC infiltration improved the outcome. Initial animal studies of gastric cancer and hepatocellular carcinoma showed that pDCs could be a successful therapeutic target. In conclusion, pDCs play a multifaceted role in GI tumors, influencing both anti-tumor immunity and tumor progression. Further research is needed to optimize their clinical application and explore combinatorial approaches.
胃肠道肿瘤是全球范围内重大的健康负担，亟需探索新型治疗方法。浆细胞样树突状细胞在肿瘤免疫中发挥关键作用，兼具抗肿瘤与促肿瘤双重效应。本文旨在综述浆细胞样树突状细胞在各类胃肠道肿瘤中的作用，并评估其作为治疗靶点的潜力。在胃癌、肝细胞癌和肝内胆管癌中，浆细胞样树突状细胞浸润增加与不良预后相关；而在食管癌、胰腺癌和结直肠癌中，其浸润则与改善预后相关。针对胃癌和肝细胞癌的初步动物研究表明，浆细胞样树突状细胞可能成为有效的治疗靶点。综上所述，浆细胞样树突状细胞在胃肠道肿瘤中扮演多面角色，既能影响抗肿瘤免疫，又可促进肿瘤进展。未来需进一步研究以优化其临床应用并探索联合治疗策略。
肿瘤(癌症)患者之家