A prospective observational study was conducted in a cohort of older adults ≥65 years (n= 329), admitted to the acute medical unit (AMU) of a tertiary hospital, to describe and compare characteristics including frailty status and clinical outcomes. Multivariable models compared older adults with and without a history of cancer to determine characteristics associated with frailty and pre-frailty. An adjusted Poisson regression model was used to compare the length of hospital stay (LOS) between the two groups. About one-fifth (22%) of the cohort had a history of cancer. The most common cancer types were prostate (n= 20), breast (n= 13), lung (n= 8) and gastrointestinal (n= 8). There was no difference in the prevalence of pre-frailty/frailty among patients with or without a history of cancer (58% vs. 57%,p> 0.05). Pre-frailty/frailty was associated with polypharmacy (OR 8.26, 95% CI: 1.74 to 39.2) and malnutrition (OR 8.91, 95% CI: 2.15 to 36.9) in patients with a history of cancer. Adjusted analysis revealed that the risk of having a longer LOS was 24% higher in older adults with a history of cancer than those without (IRR 1.24, 95% CI 1.10 to 1.41,p< 0.001). Clinicians in the AMU should be aware that older adults with a history of cancer have a higher risk of a longer LOS compared to those without.
本研究在一家三级医院急性内科病房收治的65岁及以上老年患者队列（n=329）中开展了一项前瞻性观察研究，旨在描述和比较包括衰弱状态及临床结局在内的各项特征。通过多变量模型比较有癌症病史与无癌症病史老年患者的差异，以确定与衰弱及衰弱前期相关的特征。采用校正泊松回归模型比较两组患者的住院时长。队列中约五分之一（22%）患者有癌症病史，最常见癌症类型为前列腺癌（n=20）、乳腺癌（n=13）、肺癌（n=8）和胃肠道癌症（n=8）。有癌症病史与无癌症病史患者的衰弱前期/衰弱患病率无显著差异（58% vs. 57%，p>0.05）。在癌症病史患者中，衰弱前期/衰弱与多重用药（OR 8.26，95% CI：1.74-39.2）及营养不良（OR 8.91，95% CI：2.15-36.9）显著相关。校正分析显示，有癌症病史老年患者住院时长延长的风险较无癌症病史者高24%（IRR 1.24，95% CI 1.10-1.41，p<0.001）。急性内科病房临床医师应认识到，与无癌症病史者相比，有癌症病史的老年患者住院时长延长风险更高。
肿瘤(癌症)患者之家