Pancreatic cancer is a prevalent lethal gastrointestinal cancer that generally does not show any symptoms until it reaches advanced stages, resulting in a high mortality rate. People at high risk, such as those with a family history or chronic pancreatitis, do not have a universally accepted screening protocol. Chemotherapy and radiotherapy demonstrate limited effectiveness in the management of pancreatic cancer, emphasizing the urgent need for innovative therapeutic strategies. Recent studies indicated that the complex interaction among pancreatic cancer cells within the dynamic microenvironment, comprising the extracellular matrix, cancer-associated cells, and diverse immune cells, intricately regulates the biological characteristics of the disease. Additionally, mounting evidence suggests that EVs play a crucial role as mediators in intercellular communication by the transportation of different biomolecules, such as miRNA, proteins, DNA, mRNA, and lipids, between heterogeneous cell subpopulations. This communication mediated by EVs significantly impacts multiple aspects of pancreatic cancer pathogenesis, including proliferation, angiogenesis, metastasis, and resistance to therapy. In this review, we delve into the pivotal role of EV-associated miRNAs in the progression, metastasis, and development of drug resistance in pancreatic cancer as well as their therapeutic potential as biomarkers and drug-delivery mechanisms for the management of pancreatic cancer.
胰腺癌是一种常见的致死性胃肠道恶性肿瘤，通常在进展至晚期前无明显症状，导致死亡率居高不下。对于具有家族史或慢性胰腺炎等高危人群，目前尚无普遍接受的筛查方案。化疗与放疗在胰腺癌治疗中效果有限，这凸显了对创新治疗策略的迫切需求。近期研究表明，在由细胞外基质、癌相关细胞及多种免疫细胞构成的动态微环境中，胰腺癌细胞间的复杂相互作用精细调控着该疾病的生物学特性。此外，越来越多的证据表明，细胞外囊泡通过在不同细胞亚群间转运miRNA、蛋白质、DNA、mRNA及脂质等多种生物分子，在细胞间通讯中发挥着关键介导作用。这种由细胞外囊泡介导的通讯显著影响胰腺癌发生发展的多个方面，包括增殖、血管生成、转移及治疗抵抗。本文系统综述了细胞外囊泡相关miRNA在胰腺癌进展、转移及耐药性形成中的关键作用，并探讨其作为生物标志物和药物递送载体在胰腺癌治疗中的应用潜力。
Extracellular Vesicular miRNA in Pancreatic Cancer: From Lab to Therapy
肿瘤(癌症)患者之家